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- W2772020589 abstract "BackgroundCircular RNAs (circRNAs) are a class of novel RNAs with important biological functions, and aberrant expression of circRNAs has been implicated in human diseases. However, the feasibility of using blood circRNAs as disease biomarkers is largely unknown.MethodsWe explored the potential of using human peripheral blood mononuclear cell (PBMC) circRNAs as marker molecules to diagnose active pulmonary tuberculosis (TB).FindingsFirst, we demonstrated that circRNAs are widely expressed in human PBMCs and that many are abundant enough to be detected. Second, we found that the magnitude of PBMC circRNAs in TB patients was higher than that in the paired healthy controls. Compared with host linear transcripts, the circRNAs within several pathways are disproportionately upregulated in active TB patients, including “Cytokine-cytokine receptor interaction”, “Chemokine signaling pathway”, “Neurotrophin signaling pathway”, and “Bacterial invasion of epithelial cells”. Based on the differentially expressed circRNAs within these pathways, we developed a PBMC circRNA-based molecular signature differentiating active TB patients from healthy controls. We validated the classification power of the PBMC circRNA signature in an independent cohort with the area under the receiver operating characteristic curve (AUC) at 0.946.InterpretationOur results suggest that PBMC circRNAs are potentially reliable marker molecules in TB diagnosis." @default.
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- W2772020589 date "2018-01-01" @default.
- W2772020589 modified "2023-10-13" @default.
- W2772020589 title "Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis" @default.
- W2772020589 cites W1770991729 @default.
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- W2772020589 cites W1866220599 @default.
- W2772020589 cites W1884291487 @default.
- W2772020589 cites W1966411071 @default.
- W2772020589 cites W1966557314 @default.
- W2772020589 cites W1967791012 @default.
- W2772020589 cites W1981726010 @default.
- W2772020589 cites W1991082489 @default.
- W2772020589 cites W1995653774 @default.
- W2772020589 cites W2017919052 @default.
- W2772020589 cites W2020541351 @default.
- W2772020589 cites W2021188687 @default.
- W2772020589 cites W2031130939 @default.
- W2772020589 cites W2055920203 @default.
- W2772020589 cites W2058835062 @default.
- W2772020589 cites W2064165694 @default.
- W2772020589 cites W2074759507 @default.
- W2772020589 cites W2087366831 @default.
- W2772020589 cites W2088939471 @default.
- W2772020589 cites W2098809361 @default.
- W2772020589 cites W2099320873 @default.
- W2772020589 cites W2100155969 @default.
- W2772020589 cites W2109393499 @default.
- W2772020589 cites W2110884132 @default.
- W2772020589 cites W2114104545 @default.
- W2772020589 cites W2115662330 @default.
- W2772020589 cites W2126938291 @default.
- W2772020589 cites W2133562534 @default.
- W2772020589 cites W2147625377 @default.
- W2772020589 cites W2147806662 @default.
- W2772020589 cites W2149574104 @default.
- W2772020589 cites W2160443244 @default.
- W2772020589 cites W2165446840 @default.
- W2772020589 cites W2181175475 @default.
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- W2772020589 cites W2284415752 @default.
- W2772020589 cites W2285247593 @default.
- W2772020589 cites W2285903333 @default.
- W2772020589 cites W2308074142 @default.
- W2772020589 cites W2310773425 @default.
- W2772020589 cites W2314489585 @default.
- W2772020589 cites W2342759056 @default.
- W2772020589 cites W2521361619 @default.
- W2772020589 cites W2529170873 @default.
- W2772020589 cites W2531659416 @default.
- W2772020589 cites W2545664059 @default.
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- W2772020589 cites W2567056358 @default.
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- W2772020589 cites W2592988313 @default.
- W2772020589 cites W2600581473 @default.
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- W2772020589 doi "https://doi.org/10.1016/j.ebiom.2017.12.007" @default.
- W2772020589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5828303" @default.
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