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- W2772022875 abstract "This work describes the synthesis of a series of Ru(II)‐Arene (Arene= p ‐cymene, benzene) complexes using different N ‐substituted tetrazole ligands and their PTA analogues. All the complexes have been characterized thoroughly using different analytical techniques. Antiproliferative activity of the synthesized complexes against different cell lines indicates remarkable activity of certain complexes up to nanomolar level. In few cases introduction of water soluble PTA (PTA = 1,3,5‐ triaza‐7‐phospha‐tricyclo‐[3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro analogues, particularly against Jurkat and MCF‐7 cell lines. Interaction with different biomolecules and stability of the RAPTA complexes have been explored in pseudo‐pharmacological conditions." @default.
- W2772022875 created "2017-12-22" @default.
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- W2772022875 date "2017-12-05" @default.
- W2772022875 modified "2023-10-16" @default.
- W2772022875 title "RAPTA complexes containing N‐substituted Tetrazole scaffolds: Synthesis, characterization and Antiproliferative activity" @default.
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- W2772022875 doi "https://doi.org/10.1002/aoc.4179" @default.
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