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- W2772025833 abstract "Cardiovascular or pulmonary thrombotic events are common in COPD patients. Endothelial dysfunction underlies the development of systemic vascular disturbances and the development of thrombus is dependent on the fibrinolytic balance between the release of tPA and Plasminogen Activator Inhibitor-1 (PAI-1). In this study, we aimed to investigate if there was an up-regulation of PAI-1 in COPD patients related with systemic inflammation. Methods: Fourty-four stable COPD and 41 age-matched control subjects were enrolled to study. After evaluation and pulmonary function test was performed, serum samples were obtained and stored at -80℃ until the calculation assay for serum PAI-1, YKL-40, IL-6, IL-8, MMP-9 levels. Results: Serum median PAI-1, YKL-40, IL-8, MMP-9 were significantly higher in COPD patients compared to controls (0 Conclusions: COPD is associated with systemic inflammation. Since PAI-1 level is significantly correlated with inflammatory markers, we considered that enhanced inflammatory response may alter fibrinolytic balance via serum PAI-1 levels. In COPD patients, serum YKL-40 and MMP-9 levels were the most important determinants for PAI-1 levels." @default.
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- W2772025833 date "2017-09-01" @default.
- W2772025833 modified "2023-09-24" @default.
- W2772025833 title "The relation between plasminogen activator inhibitor-1 (PAI-1) and inflammatory markers in COPD: A possible risk factor of inflammation-induced thrombosis" @default.
- W2772025833 doi "https://doi.org/10.1183/1393003.congress-2017.pa1009" @default.
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