FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772029902> ?p ?o ?g. }

• W2772029902 abstract "The experiments reported here demonstrate that the mechanical sensitivity of peripheral nerve fibres typically seen after injury can be induced without overtly injuring the nerve, but by simply applying colchicine topically to the nerve. In cats anaesthetised with pentobarbitone sodium, the medial gastrocnemius nerve was exposed and 10 mM colchicine applied topically for 15 min. The animals recovered from the operation normally and showed no subsequent motor deficit. Six days later animals were re-anaesthetised, a laminectomy carried out and responses recorded in single afferents at the level of the dorsal root. It was found that many afferents, particularly those with conduction velocities in the group II–III range, had become sensitive to local mechanical stimulation of the nerve in the region treated with colchicine and showed slowly adapting responses to stretch of the nerve. Many of the smaller fibres exhibited spontaneous activity. Mechanically sensitive afferents exhibited impulse conduction blocks at the colchicine-treated site. Some afferents, which appeared to conduct impulses normally through the treated region, were associated with muscle receptors having normal response properties. However, other muscle receptors were clearly abnormal and were insensitive to muscle stretch or contraction or exhibited only phasic responses. When the nerve was cut proximal to the colchicine-treated site, some, but not all, spontaneous activity was abolished. It was subsequently shown using a collision technique that the activity in some axons had its origin in the cell body in the dorsal root ganglion. In one experiment, it was shown that after nerve section proximal to the colchicine-treated region three of five axons switched their activity from a peripheral to a central origin. It is postulated that colchicine disrupts fast axonal transport of mechanically sensitive or voltage-sensitive ion channels, from the cell body to the peripheral terminals of the axons, leading to an accumulation of these channels at the treated site. This induces mechanical sensitivity and spontaneous activity. It is postulated that interruption of a retrogradely transported signal induces the spontaneous activity in the cell body. These experiments suggest that an important influence is exerted by the cell body on the peripheral terminals of mechanoreceptors to confer on them their normal response properties." @default.
• W2772029902 created "2017-12-22" @default.
• W2772029902 creator A5060496510 @default.
• W2772029902 creator A5083639601 @default.
• W2772029902 date "1997-01-01" @default.
• W2772029902 modified "2023-09-27" @default.
• W2772029902 title "Mechanical sensitivity of muscle afferents in a nerve treated with colchicine" @default.
• W2772029902 hasPublicationYear "1997" @default.
• W2772029902 type Work @default.
• W2772029902 sameAs 2772029902 @default.
• W2772029902 citedByCount "1" @default.
• W2772029902 crossrefType "journal-article" @default.
• W2772029902 hasAuthorship W2772029902A5060496510 @default.
• W2772029902 hasAuthorship W2772029902A5083639601 @default.
• W2772029902 hasConcept C105702510 @default.
• W2772029902 hasConcept C126322002 @default.
• W2772029902 hasConcept C134018914 @default.
• W2772029902 hasConcept C140530291 @default.
• W2772029902 hasConcept C185592680 @default.
• W2772029902 hasConcept C24998067 @default.
• W2772029902 hasConcept C2776281502 @default.
• W2772029902 hasConcept C2776636253 @default.
• W2772029902 hasConcept C2778828891 @default.
• W2772029902 hasConcept C2779263132 @default.
• W2772029902 hasConcept C42219234 @default.
• W2772029902 hasConcept C71924100 @default.
• W2772029902 hasConceptScore W2772029902C105702510 @default.
• W2772029902 hasConceptScore W2772029902C126322002 @default.
• W2772029902 hasConceptScore W2772029902C134018914 @default.
• W2772029902 hasConceptScore W2772029902C140530291 @default.
• W2772029902 hasConceptScore W2772029902C185592680 @default.
• W2772029902 hasConceptScore W2772029902C24998067 @default.
• W2772029902 hasConceptScore W2772029902C2776281502 @default.
• W2772029902 hasConceptScore W2772029902C2776636253 @default.
• W2772029902 hasConceptScore W2772029902C2778828891 @default.
• W2772029902 hasConceptScore W2772029902C2779263132 @default.
• W2772029902 hasConceptScore W2772029902C42219234 @default.
• W2772029902 hasConceptScore W2772029902C71924100 @default.
• W2772029902 hasLocation W27720299021 @default.
• W2772029902 hasOpenAccess W2772029902 @default.
• W2772029902 hasPrimaryLocation W27720299021 @default.
• W2772029902 hasRelatedWork W1582090951 @default.
• W2772029902 hasRelatedWork W1623378741 @default.
• W2772029902 hasRelatedWork W1979371835 @default.
• W2772029902 hasRelatedWork W1993170303 @default.
• W2772029902 hasRelatedWork W1998756145 @default.
• W2772029902 hasRelatedWork W2000869264 @default.
• W2772029902 hasRelatedWork W2001190654 @default.
• W2772029902 hasRelatedWork W2006868908 @default.
• W2772029902 hasRelatedWork W2014113611 @default.
• W2772029902 hasRelatedWork W2018386924 @default.
• W2772029902 hasRelatedWork W2028245367 @default.
• W2772029902 hasRelatedWork W2028605406 @default.
• W2772029902 hasRelatedWork W2039697499 @default.
• W2772029902 hasRelatedWork W2049908414 @default.
• W2772029902 hasRelatedWork W2060351148 @default.
• W2772029902 hasRelatedWork W2087855378 @default.
• W2772029902 hasRelatedWork W2109479896 @default.
• W2772029902 hasRelatedWork W2402918346 @default.
• W2772029902 hasRelatedWork W2422202397 @default.
• W2772029902 hasRelatedWork W2440946723 @default.
• W2772029902 isParatext "false" @default.
• W2772029902 isRetracted "false" @default.
• W2772029902 magId "2772029902" @default.
• W2772029902 workType "article" @default.