FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772036742> ?p ?o ?g. }

• W2772036742 endingPage "5948" @default.
• W2772036742 startingPage "5937" @default.
• W2772036742 abstract "Three-dimensional (3D) cancer models are overlooking the scientific landscape with the primary goal of bridging the gaps between two-dimensional (2D) cell lines, animal models and clinical research. Here, we describe an innovative tissue engineering approach applied to colorectal cancer (CRC) starting from decellularized human biopsies in order to generate an organotypic 3D-bioactive model. This in vitro 3D system recapitulates the ultrastructural environment of native tissue as demonstrated by histology, immunohistochemistry, immunofluorescence and scanning electron microscopy analyses. Mass spectrometry of proteome and secretome confirmed a different stromal composition between decellularized healthy mucosa and CRC in terms of structural and secreted proteins. Importantly, we proved that our 3D acellular matrices retained their biological properties: using CAM assay, we observed a decreased angiogenic potential in decellularized CRC compared with healthy tissue, caused by direct effect of DEFA3. We demonstrated that following a 5 days of recellularization with HT-29 cell line, the 3D tumor matrices induced an over-expression of IL-8, a DEFA3-mediated pathway and a mandatory chemokine in cancer growth and proliferation. Given the biological activity maintained by the scaffolds after decellularization, we believe this approach is a powerful tool for future pre-clinical research and screenings." @default.
• W2772036742 created "2017-12-22" @default.
• W2772036742 creator A5001559084 @default.
• W2772036742 creator A5004814157 @default.
• W2772036742 creator A5012796096 @default.
• W2772036742 creator A5021618906 @default.
• W2772036742 creator A5024798356 @default.
• W2772036742 creator A5025418303 @default.
• W2772036742 creator A5029334360 @default.
• W2772036742 creator A5029995182 @default.
• W2772036742 creator A5033338213 @default.
• W2772036742 creator A5046301295 @default.
• W2772036742 creator A5048560367 @default.
• W2772036742 creator A5051215257 @default.
• W2772036742 creator A5053030044 @default.
• W2772036742 creator A5055252814 @default.
• W2772036742 creator A5086295470 @default.
• W2772036742 creator A5089455026 @default.
• W2772036742 date "2018-02-27" @default.
• W2772036742 modified "2023-10-17" @default.
• W2772036742 title "Decellularized colorectal cancer matrix as bioactive microenvironment for in vitro 3D cancer research" @default.
• W2772036742 cites W1493975488 @default.
• W2772036742 cites W1572983296 @default.
• W2772036742 cites W1917894265 @default.
• W2772036742 cites W1966008750 @default.
• W2772036742 cites W1968769948 @default.
• W2772036742 cites W1973254683 @default.
• W2772036742 cites W1977231563 @default.
• W2772036742 cites W1979510594 @default.
• W2772036742 cites W1979700784 @default.
• W2772036742 cites W1983762572 @default.
• W2772036742 cites W1988075836 @default.
• W2772036742 cites W1994192407 @default.
• W2772036742 cites W2010251891 @default.
• W2772036742 cites W2011945355 @default.
• W2772036742 cites W2028957277 @default.
• W2772036742 cites W2029865511 @default.
• W2772036742 cites W2030605936 @default.
• W2772036742 cites W2030958037 @default.
• W2772036742 cites W2033643156 @default.
• W2772036742 cites W2044433401 @default.
• W2772036742 cites W2044578399 @default.
• W2772036742 cites W2057381962 @default.
• W2772036742 cites W2066109395 @default.
• W2772036742 cites W2073407938 @default.
• W2772036742 cites W2073982125 @default.
• W2772036742 cites W2076081218 @default.
• W2772036742 cites W2080157242 @default.
• W2772036742 cites W2080547568 @default.
• W2772036742 cites W2082081720 @default.
• W2772036742 cites W2088899354 @default.
• W2772036742 cites W2103919594 @default.
• W2772036742 cites W2107291281 @default.
• W2772036742 cites W2113771101 @default.
• W2772036742 cites W2125970092 @default.
• W2772036742 cites W2143950546 @default.
• W2772036742 cites W2161830060 @default.
• W2772036742 cites W2167363836 @default.
• W2772036742 cites W2167652248 @default.
• W2772036742 cites W2168775089 @default.
• W2772036742 cites W2230944881 @default.
• W2772036742 cites W2237361742 @default.
• W2772036742 cites W2474578758 @default.
• W2772036742 cites W2545703737 @default.
• W2772036742 cites W2587225206 @default.
• W2772036742 cites W2593144838 @default.
• W2772036742 doi "https://doi.org/10.1002/jcp.26403" @default.
• W2772036742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29244195" @default.
• W2772036742 hasPublicationYear "2018" @default.
• W2772036742 type Work @default.
• W2772036742 sameAs 2772036742 @default.
• W2772036742 citedByCount "54" @default.
• W2772036742 countsByYear W27720367422018 @default.
• W2772036742 countsByYear W27720367422019 @default.
• W2772036742 countsByYear W27720367422020 @default.
• W2772036742 countsByYear W27720367422021 @default.
• W2772036742 countsByYear W27720367422022 @default.
• W2772036742 countsByYear W27720367422023 @default.
• W2772036742 crossrefType "journal-article" @default.
• W2772036742 hasAuthorship W2772036742A5001559084 @default.
• W2772036742 hasAuthorship W2772036742A5004814157 @default.
• W2772036742 hasAuthorship W2772036742A5012796096 @default.
• W2772036742 hasAuthorship W2772036742A5021618906 @default.
• W2772036742 hasAuthorship W2772036742A5024798356 @default.
• W2772036742 hasAuthorship W2772036742A5025418303 @default.
• W2772036742 hasAuthorship W2772036742A5029334360 @default.
• W2772036742 hasAuthorship W2772036742A5029995182 @default.
• W2772036742 hasAuthorship W2772036742A5033338213 @default.
• W2772036742 hasAuthorship W2772036742A5046301295 @default.
• W2772036742 hasAuthorship W2772036742A5048560367 @default.
• W2772036742 hasAuthorship W2772036742A5051215257 @default.
• W2772036742 hasAuthorship W2772036742A5053030044 @default.
• W2772036742 hasAuthorship W2772036742A5055252814 @default.
• W2772036742 hasAuthorship W2772036742A5086295470 @default.
• W2772036742 hasAuthorship W2772036742A5089455026 @default.
• W2772036742 hasConcept C121608353 @default.
• W2772036742 hasConcept C142724271 @default.
• W2772036742 hasConcept C163688615 @default.

• next