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- W2772037738 abstract "Background and Methods: We aimed to compare functional status in men and women on the liver transplant (LT) wait-list. Consecutive adult outpatients (n=340) listed for LT at one center (96% recruitment rate) underwent 4 frailty/functional impairment assessments at a single time point: Fried Frailty, gait speed, Activities of Daily Living (ADL), and Instrumental ADL (IADL) scales. Chi-square and Kruskal-wallis tests compared differences by gender. Using competing risks models, we assessed the association between the Fried Frailty Instrument and wait-list mortality (death/delisting for being too sick for LT) given its validity and prognostic utility in other non-elderly populations. Results: Of 340 LT candidates, 33% were women. Men and women were similar by median follow up (11 vs 10mo), age (60 vs 60yr), body mass index (29 vs 28), %ascites (34 vs 36), %encephalopathy (17 vs 19) [p>0.05], but differed by %HCC (31 vs 18), %hypertension (48 vs 36), bilirubin (2.2 vs 2.6 mg/dL), creatinine (1.0 vs 0.9 mg/dL), %on dialysis (3 vs 7), MELD [15 (IQR 12-18) vs 15 (13-19)] [p<0.05 for each]. Women displayed higher rates of functional impairment (Table).Table: No Caption available.Wait-list mortality occurred in 20% frail and 10% not frail candidates (p=0.046). Death/delisting occurred in 9% of non-frail women, 9% of frail women, 11% of non-frail men, but 27% of frail men (p=0.03). Compared to non-frail women, frail men had a 3.4 fold increased risk of wait-list mortality (Figure).Figure: No Caption available.Conclusions: Among LT candidates, women display higher rates of functional impairment than men. Frailty is a stronger predictor of wait-list mortality in men, independent of MELD score." @default.
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- W2772037738 date "2014-07-01" @default.
- W2772037738 modified "2023-09-26" @default.
- W2772037738 title "Gender Differences in Frailty and Functional Impairment Among Liver Transplant Candidates." @default.
- W2772037738 doi "https://doi.org/10.1097/00007890-201407151-02641" @default.
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