FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772038474> ?p ?o ?g. }

• W2772038474 endingPage "702" @default.
• W2772038474 startingPage "690" @default.
• W2772038474 abstract "Ephedra is likely one of the oldest medicinal plants still currently in use. In folk medicine, extracts of Ephedra foeminea are commonly used to treat cancer patients. In relation to its traditional use, the aim of the present study was to determine the cytotoxic activity in vitro of E. foeminea extracts on cancer and non-cancer cells. Cell viability was determined using XTT assay, induction of apoptosis by cell sorting and caspase-3 inhibition, and the effects on cell cytoskeleton structure were detected using cell transfection utilizing different cytoskeleton markers. Chemical profiling, analysis of active extracts and identification of compounds was done using high pressure liquid chromatography (HPLC) and gas chromatography-mass spectroscopy (GCMS). E. foeminea leaf ethanol extract and E. foeminea fruit juice reduced cancer cell viability in vitro, whereas the water extract reduced cytotoxic activity in all cell lines. The extract's cytotoxic activity was conveyed at least partially via the induction of caspase 3-dependent cell apoptosis, and enhanced by the addition of Taxol. Both E. foeminea ethanol leaf extract and fruit juice affected actin-stained but not tubulin-stained filaments. Ethanol extract promoted the formation of invadopodia-like structures and fruit juice promoted the formation of large focal adhesion points in the treated cells. Active sub-fractions of E. foeminea extracts were found to contain several compounds including trans-sinapyl alcohol and trans-sinapaldehyde derivative. Key words: Ephedra foeminea, plant extract, cancer cells, actin, invadopodia, apoptosis." @default.
• W2772038474 created "2017-12-22" @default.
• W2772038474 creator A5003016784 @default.
• W2772038474 creator A5006359012 @default.
• W2772038474 creator A5007055902 @default.
• W2772038474 creator A5020908176 @default.
• W2772038474 creator A5041608006 @default.
• W2772038474 creator A5048769713 @default.
• W2772038474 creator A5053302457 @default.
• W2772038474 creator A5063682013 @default.
• W2772038474 creator A5067752611 @default.
• W2772038474 creator A5073511228 @default.
• W2772038474 creator A5075562261 @default.
• W2772038474 creator A5076961975 @default.
• W2772038474 creator A5083451638 @default.
• W2772038474 creator A5087352410 @default.
• W2772038474 creator A5089273761 @default.
• W2772038474 creator A5091146292 @default.
• W2772038474 date "2017-11-17" @default.
• W2772038474 modified "2023-09-27" @default.
• W2772038474 title "Effect of Ephedra foeminea active compounds on cell viability and actin structures in cancer cell lines" @default.
• W2772038474 cites W1521512767 @default.
• W2772038474 cites W1645427546 @default.
• W2772038474 cites W1971729562 @default.
• W2772038474 cites W1978143593 @default.
• W2772038474 cites W1982241406 @default.
• W2772038474 cites W1997774562 @default.
• W2772038474 cites W2015904361 @default.
• W2772038474 cites W2027785477 @default.
• W2772038474 cites W2067299834 @default.
• W2772038474 cites W2071021121 @default.
• W2772038474 cites W2073739784 @default.
• W2772038474 cites W2080818154 @default.
• W2772038474 cites W2100085214 @default.
• W2772038474 cites W2110129865 @default.
• W2772038474 cites W2119269592 @default.
• W2772038474 cites W2131554707 @default.
• W2772038474 cites W2132799659 @default.
• W2772038474 cites W2133101055 @default.
• W2772038474 cites W2141206344 @default.
• W2772038474 cites W2162643935 @default.
• W2772038474 cites W2184186392 @default.
• W2772038474 cites W2344075334 @default.
• W2772038474 cites W2346147502 @default.
• W2772038474 doi "https://doi.org/10.5897/jmpr2017.6471" @default.
• W2772038474 hasPublicationYear "2017" @default.
• W2772038474 type Work @default.
• W2772038474 sameAs 2772038474 @default.
• W2772038474 citedByCount "8" @default.
• W2772038474 countsByYear W27720384742018 @default.
• W2772038474 countsByYear W27720384742020 @default.
• W2772038474 countsByYear W27720384742021 @default.
• W2772038474 countsByYear W27720384742022 @default.
• W2772038474 countsByYear W27720384742023 @default.
• W2772038474 crossrefType "journal-article" @default.
• W2772038474 hasAuthorship W2772038474A5003016784 @default.
• W2772038474 hasAuthorship W2772038474A5006359012 @default.
• W2772038474 hasAuthorship W2772038474A5007055902 @default.
• W2772038474 hasAuthorship W2772038474A5020908176 @default.
• W2772038474 hasAuthorship W2772038474A5041608006 @default.
• W2772038474 hasAuthorship W2772038474A5048769713 @default.
• W2772038474 hasAuthorship W2772038474A5053302457 @default.
• W2772038474 hasAuthorship W2772038474A5063682013 @default.
• W2772038474 hasAuthorship W2772038474A5067752611 @default.
• W2772038474 hasAuthorship W2772038474A5073511228 @default.
• W2772038474 hasAuthorship W2772038474A5075562261 @default.
• W2772038474 hasAuthorship W2772038474A5076961975 @default.
• W2772038474 hasAuthorship W2772038474A5083451638 @default.
• W2772038474 hasAuthorship W2772038474A5087352410 @default.
• W2772038474 hasAuthorship W2772038474A5089273761 @default.
• W2772038474 hasAuthorship W2772038474A5091146292 @default.
• W2772038474 hasBestOaLocation W27720384741 @default.
• W2772038474 hasConcept C121608353 @default.
• W2772038474 hasConcept C1491633281 @default.
• W2772038474 hasConcept C185592680 @default.
• W2772038474 hasConcept C2994372470 @default.
• W2772038474 hasConcept C53227056 @default.
• W2772038474 hasConcept C54355233 @default.
• W2772038474 hasConcept C55493867 @default.
• W2772038474 hasConcept C556039675 @default.
• W2772038474 hasConcept C71924100 @default.
• W2772038474 hasConcept C86803240 @default.
• W2772038474 hasConcept C95444343 @default.
• W2772038474 hasConcept C96232424 @default.
• W2772038474 hasConceptScore W2772038474C121608353 @default.
• W2772038474 hasConceptScore W2772038474C1491633281 @default.
• W2772038474 hasConceptScore W2772038474C185592680 @default.
• W2772038474 hasConceptScore W2772038474C2994372470 @default.
• W2772038474 hasConceptScore W2772038474C53227056 @default.
• W2772038474 hasConceptScore W2772038474C54355233 @default.
• W2772038474 hasConceptScore W2772038474C55493867 @default.
• W2772038474 hasConceptScore W2772038474C556039675 @default.
• W2772038474 hasConceptScore W2772038474C71924100 @default.
• W2772038474 hasConceptScore W2772038474C86803240 @default.
• W2772038474 hasConceptScore W2772038474C95444343 @default.
• W2772038474 hasConceptScore W2772038474C96232424 @default.
• W2772038474 hasIssue "43" @default.
• W2772038474 hasLocation W27720384741 @default.

• next