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• W2772043062 abstract "Historically, donor age for lung transplantation must not exceed 55 years. That has increased to 65 years, however, older donors are also considered. There is no well-defined upper cut off, and there are no convincing absolute contraindications against the transplantation of older donor lungs. Since 05/2010, we accepted 70+ year old donor lungs on a regular basis in our program and here we present outcomes of these transplantations and compare to that of donors <70 years. Lung transplantations performed at our centre between 05/2010 and 06/2013 were retrospectively analyzed. Outcome parameters included amongst others freedom from primary graft dysfunction grade 3 (PGD3; ISHLT classification) and 1-year mortality. Seventeen patients (lung fibrosis n=7, emphysema n=5, idiopathic pulmonary artery hypertension n=2, GvHD n=2, sarcoidosis n=1) received lung transplants from donors 70 years of age or older. Median donor age was 71 [range 70-76]. During the same time period 329 lung transplantations were performed from donors 69 years of age or younger (median 46 years [range 1-69]) in our program. Median recipient age was 61 [range 49-64] vs. 51 [range 4-67] years, indicating preferred allocation of 70+ donor lungs to older recipients. Important postoperative indicators of transplant outcome are freedom from PGD3 at any time: 14/17 (82.4%) in the older donor and 279/329 (84.8%) in the regular donor cohort; and median duration of postoperative mechanical ventilation: 29.0 hours vs. 24.0 hours. The median postoperative intensive care stay was 4 vs. 3 days and the total hospital stay 25 vs. 23 days. Hospital mortality was 0.0% vs. 5.2% (p=0.65; Kaplan-Meier-survival curves) and overall survival of the recipients was 100% in the older donor and 92.05% in the regular donor group at 1 year (p=0.44, Kaplan-Meier-survival). Two late deaths beyond one year occurred in the older donor group at days 389 and 523, both in patients that had developed bronchiolitis obliterans syndrome. Lungs from donors 70 years of age and older can be used for transplantation. Early outcome is equivalent to what can be expected from transplantation of lungs from younger donors and thus we intend to continue our practice. While common sense may advise to preferentially allocate older donors towards older recipients, there is no direct evidence dictating for doing so." @default.
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• W2772043062 date "2014-07-01" @default.
• W2772043062 modified "2023-10-16" @default.
• W2772043062 title "Extending Donor Criteria in Lung Transplantation - Donors 70 Years and Older." @default.
• W2772043062 doi "https://doi.org/10.1097/00007890-201407151-00583" @default.
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