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• W2772044986 abstract "Recently, designed platelet shaped micron particles that are composed of nano primary particles, called MicNo (= Micron + naNo) particles, have been developed to exploit the benefits of nano size, while removing the adverse effects of nanoparticles. It has been shown that MicNo-ZnO particles exhibit both micron and nanosized particle characteristics. Although physical and chemical properties of MicNo-ZnO particles have been studied, their biocompatibility has not yet been evaluated. Accordingly, the research objective of this study was to evaluate in vitro cytotoxicity, genotoxicity and phototoxicity behaviors of designed MicNo-ZnO particles over human epidermal keratinocyte (HaCaT) cells. MicNo-ZnO particles exhibit much less cytotoxicity with IC50 concentrations between 40 and 50 μg/ml, genotoxicity above 40 μg/ml and lower photo genotoxicity under UVA on HaCaT than the ZnO nanoparticles. Although their chemistries are the same, the source of this difference in toxicity values may be attributed to size differences between the particles that are probably due to their ability to penetrate into the cells. In the present study, the expansive and detailed in vitro toxicity tests show that the biocompatibility of MicNo-ZnO particles is much better than that of the ZnO nanoparticles. Consequently, MicNo-ZnO particles can be considered an important active ingredient alternative for sunscreen applications due to their safer characteristics with respect to ZnO nanoparticles." @default.
• W2772044986 created "2017-12-22" @default.
• W2772044986 creator A5004194141 @default.
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• W2772044986 date "2018-03-01" @default.
• W2772044986 modified "2023-10-16" @default.
• W2772044986 title "Biocompatibility of designed MicNo-ZnO particles: Cytotoxicity, genotoxicity and phototoxicity in human skin keratinocyte cells" @default.
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• W2772044986 doi "https://doi.org/10.1016/j.tiv.2017.12.004" @default.
• W2772044986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29223573" @default.
• W2772044986 hasPublicationYear "2018" @default.
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