FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772048140> ?p ?o ?g. }

• W2772048140 endingPage "940" @default.
• W2772048140 startingPage "927" @default.
• W2772048140 abstract "Human GSTP1-1 is one of the most important proteins, which overexpresses in a large number of human tumours and is involved in the development of resistance to several anticancer drugs. So, it has become an important target in cancer treatment. In this study, 12 benzothiazole derivatives were synthesized and screened for their in vitro inhibitory activity for hGSTP1-1. Among these compounds, two of them (compounds #2 and #5) have been found to be the leads when compared with the reference drug etoposide. In order to analyse the structure–activity relationships (SARs) and to investigate the binding side interactions of the observed lead compounds, a HipHop pharmacophore model was generated and the molecular docking studies were performed by using CDocker method. In conclusion, it is observed that the lead compounds #2 and #5 possessed inhibitory activity on the hGSTP1-1 by binding to the H-site as a substrate in which the para position of the phenyl ring of the benzamide moiety on the benzothiazole ring is important. Substitution at this position with a hydrophobic group that reduces the electron density at the phenyl ring is required for the interaction with the H side active residue Tyr108." @default.
• W2772048140 created "2017-12-22" @default.
• W2772048140 creator A5009794122 @default.
• W2772048140 creator A5033650828 @default.
• W2772048140 creator A5077289224 @default.
• W2772048140 creator A5080145082 @default.
• W2772048140 creator A5084048612 @default.
• W2772048140 date "2017-11-02" @default.
• W2772048140 modified "2023-10-16" @default.
• W2772048140 title "Synthesis and activity mechanism of some novel 2-substituted benzothiazoles as hGSTP1-1 enzyme inhibitors" @default.
• W2772048140 cites W1581414347 @default.
• W2772048140 cites W1988022715 @default.
• W2772048140 cites W2002195549 @default.
• W2772048140 cites W2004783926 @default.
• W2772048140 cites W2031336599 @default.
• W2772048140 cites W2037870372 @default.
• W2772048140 cites W2040661536 @default.
• W2772048140 cites W2042007689 @default.
• W2772048140 cites W2048414704 @default.
• W2772048140 cites W2054118324 @default.
• W2772048140 cites W2057589519 @default.
• W2772048140 cites W2059609559 @default.
• W2772048140 cites W2079555650 @default.
• W2772048140 cites W2115955554 @default.
• W2772048140 cites W2128090040 @default.
• W2772048140 cites W2128423544 @default.
• W2772048140 cites W2140268969 @default.
• W2772048140 cites W2150081412 @default.
• W2772048140 cites W2153124384 @default.
• W2772048140 cites W2153274471 @default.
• W2772048140 cites W2156053468 @default.
• W2772048140 cites W2161634702 @default.
• W2772048140 cites W2176327465 @default.
• W2772048140 cites W2178273593 @default.
• W2772048140 cites W2295816941 @default.
• W2772048140 cites W2343445198 @default.
• W2772048140 cites W2612992392 @default.
• W2772048140 cites W4238581030 @default.
• W2772048140 cites W937093307 @default.
• W2772048140 cites W2032466795 @default.
• W2772048140 doi "https://doi.org/10.1080/1062936x.2017.1402820" @default.
• W2772048140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29206502" @default.
• W2772048140 hasPublicationYear "2017" @default.
• W2772048140 type Work @default.
• W2772048140 sameAs 2772048140 @default.
• W2772048140 citedByCount "6" @default.
• W2772048140 countsByYear W27720481402018 @default.
• W2772048140 countsByYear W27720481402019 @default.
• W2772048140 countsByYear W27720481402020 @default.
• W2772048140 countsByYear W27720481402022 @default.
• W2772048140 countsByYear W27720481402023 @default.
• W2772048140 crossrefType "journal-article" @default.
• W2772048140 hasAuthorship W2772048140A5009794122 @default.
• W2772048140 hasAuthorship W2772048140A5033650828 @default.
• W2772048140 hasAuthorship W2772048140A5077289224 @default.
• W2772048140 hasAuthorship W2772048140A5080145082 @default.
• W2772048140 hasAuthorship W2772048140A5084048612 @default.
• W2772048140 hasConcept C159110408 @default.
• W2772048140 hasConcept C178790620 @default.
• W2772048140 hasConcept C181199279 @default.
• W2772048140 hasConcept C185592680 @default.
• W2772048140 hasConcept C204921945 @default.
• W2772048140 hasConcept C21951064 @default.
• W2772048140 hasConcept C2776568683 @default.
• W2772048140 hasConcept C2777456753 @default.
• W2772048140 hasConcept C2780231548 @default.
• W2772048140 hasConcept C2780378348 @default.
• W2772048140 hasConcept C41183919 @default.
• W2772048140 hasConcept C41685203 @default.
• W2772048140 hasConcept C521977710 @default.
• W2772048140 hasConcept C55493867 @default.
• W2772048140 hasConcept C56173144 @default.
• W2772048140 hasConcept C71240020 @default.
• W2772048140 hasConcept C71924100 @default.
• W2772048140 hasConceptScore W2772048140C159110408 @default.
• W2772048140 hasConceptScore W2772048140C178790620 @default.
• W2772048140 hasConceptScore W2772048140C181199279 @default.
• W2772048140 hasConceptScore W2772048140C185592680 @default.
• W2772048140 hasConceptScore W2772048140C204921945 @default.
• W2772048140 hasConceptScore W2772048140C21951064 @default.
• W2772048140 hasConceptScore W2772048140C2776568683 @default.
• W2772048140 hasConceptScore W2772048140C2777456753 @default.
• W2772048140 hasConceptScore W2772048140C2780231548 @default.
• W2772048140 hasConceptScore W2772048140C2780378348 @default.
• W2772048140 hasConceptScore W2772048140C41183919 @default.
• W2772048140 hasConceptScore W2772048140C41685203 @default.
• W2772048140 hasConceptScore W2772048140C521977710 @default.
• W2772048140 hasConceptScore W2772048140C55493867 @default.
• W2772048140 hasConceptScore W2772048140C56173144 @default.
• W2772048140 hasConceptScore W2772048140C71240020 @default.
• W2772048140 hasConceptScore W2772048140C71924100 @default.
• W2772048140 hasIssue "11" @default.
• W2772048140 hasLocation W27720481401 @default.
• W2772048140 hasLocation W27720481402 @default.
• W2772048140 hasOpenAccess W2772048140 @default.
• W2772048140 hasPrimaryLocation W27720481401 @default.
• W2772048140 hasRelatedWork W1815473782 @default.
• W2772048140 hasRelatedWork W1972951789 @default.

• next