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• W2772048458 endingPage "e0189381" @default.
• W2772048458 startingPage "e0189381" @default.
• W2772048458 abstract "The multiple extremes resistant bacterium Deinococcus radiodurans is able to withstand harsh conditions of simulated outer space environment. The Tanpopo orbital mission performs a long-term space exposure of D. radiodurans aiming to investigate the possibility of interplanetary transfer of life. The revealing of molecular machinery responsible for survivability of D. radiodurans in the outer space environment can improve our understanding of underlying stress response mechanisms. In this paper, we have evaluated the molecular response of D. radiodurans after the exposure to space-related conditions of UVC irradiation and vacuum. Notably, scanning electron microscopy investigations showed that neither morphology nor cellular integrity of irradiated cells was affected, while integrated proteomic and metabolomic analysis revealed numerous molecular alterations in metabolic and stress response pathways. Several molecular key mechanisms of D. radiodurans, including the tricarboxylic acid cycle, the DNA damage response systems, ROS scavenging systems and transcriptional regulators responded in order to cope with the stressful situation caused by UVC irradiation under vacuum conditions. These results reveal the effectiveness of the integrative proteometabolomic approach as a tool in molecular analysis of microbial stress response caused by space-related factors." @default.
• W2772048458 created "2017-12-22" @default.
• W2772048458 creator A5022853461 @default.
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• W2772048458 date "2017-12-15" @default.
• W2772048458 modified "2023-10-16" @default.
• W2772048458 title "Proteometabolomic response of Deinococcus radiodurans exposed to UVC and vacuum conditions: Initial studies prior to the Tanpopo space mission" @default.
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• W2772048458 doi "https://doi.org/10.1371/journal.pone.0189381" @default.
• W2772048458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5731708" @default.
• W2772048458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29244852" @default.
• W2772048458 hasPublicationYear "2017" @default.
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