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- W2772059359 endingPage "4227" @default.
- W2772059359 startingPage "4217" @default.
- W2772059359 abstract "The discovery, characterization, and clinical development of glucagon-like-peptide-1 (GLP-1) spans more than 30 years and includes contributions from multiple investigators, science recognized by the 2017 Harrington Award Prize for Innovation in Medicine. Herein, we provide perspectives on the historical events and key experimental findings establishing the biology of GLP-1 as an insulin-stimulating glucoregulatory hormone. Important attributes of GLP-1 action and enteroendocrine science are reviewed, with emphasis on mechanistic advances and clinical proof-of-concept studies. The discovery that GLP-2 promotes mucosal growth in the intestine is described, and key findings from both preclinical studies and the GLP-2 clinical development program for short bowel syndrome (SBS) are reviewed. Finally, we summarize recent progress in GLP biology, highlighting emerging concepts and scientific insights with translational relevance." @default.
- W2772059359 created "2017-12-22" @default.
- W2772059359 creator A5034913449 @default.
- W2772059359 creator A5057472647 @default.
- W2772059359 creator A5065850266 @default.
- W2772059359 date "2017-12-01" @default.
- W2772059359 modified "2023-10-17" @default.
- W2772059359 title "Discovery, characterization, and clinical development of the glucagon-like peptides" @default.
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