Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772060643> ?p ?o ?g. }
- W2772060643 abstract "Abstract Stargardt disease is a juvenile onset retinal degeneration, associated with elevated levels of lipofuscin and its bis-retinoid components, such as N -retinylidene- N -retinylethanolamine (A2E). However, the pathogenesis of Stargardt is still poorly understood and targeted treatments are not available. Utilizing high spatial and high mass resolution matrix assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS), we determined alterations of lipid profiles specifically localized to the retinal pigment epithelium (RPE) in Abca4 −/− Stargardt model mice compared to their relevant background strain. Extensive analysis by LC-MS/MS in both positive and negative ion mode was required to accurately confirm the identity of one highly expressed lipid class, bis(monoacylgylercoro)phosphate (BMP) lipids, and to distinguish them from isobaric species. The same BMP lipids were also detected in the RPE of healthy human retina. BMP lipids have been previously associated with the endosomal/lysosomal storage diseases Niemann-Pick and neuronal ceroid lipofuscinosis and have been reported to regulate cholesterol levels in endosomes. These results suggest that perturbations in lipid metabolism associated with late endosomal/lysosomal dysfunction may play a role in the pathogenesis of Stargardt disease and is evidenced in human retinas." @default.
- W2772060643 created "2017-12-22" @default.
- W2772060643 creator A5022215889 @default.
- W2772060643 creator A5043823252 @default.
- W2772060643 creator A5048793396 @default.
- W2772060643 creator A5059275651 @default.
- W2772060643 creator A5061432494 @default.
- W2772060643 creator A5086395819 @default.
- W2772060643 creator A5086889001 @default.
- W2772060643 creator A5090194196 @default.
- W2772060643 creator A5091850113 @default.
- W2772060643 date "2017-12-11" @default.
- W2772060643 modified "2023-10-18" @default.
- W2772060643 title "Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas" @default.
- W2772060643 cites W1494048878 @default.
- W2772060643 cites W1523693806 @default.
- W2772060643 cites W1536269846 @default.
- W2772060643 cites W1573040585 @default.
- W2772060643 cites W1849946337 @default.
- W2772060643 cites W1857166068 @default.
- W2772060643 cites W1964435465 @default.
- W2772060643 cites W1969137136 @default.
- W2772060643 cites W1982211641 @default.
- W2772060643 cites W1984158845 @default.
- W2772060643 cites W1985540529 @default.
- W2772060643 cites W1989558725 @default.
- W2772060643 cites W1990830281 @default.
- W2772060643 cites W1991544676 @default.
- W2772060643 cites W1994172606 @default.
- W2772060643 cites W1996450462 @default.
- W2772060643 cites W1997925124 @default.
- W2772060643 cites W2000915110 @default.
- W2772060643 cites W2002657202 @default.
- W2772060643 cites W2006962138 @default.
- W2772060643 cites W2007147590 @default.
- W2772060643 cites W2013238661 @default.
- W2772060643 cites W2017397456 @default.
- W2772060643 cites W2019453308 @default.
- W2772060643 cites W2019731198 @default.
- W2772060643 cites W2020054871 @default.
- W2772060643 cites W2021727046 @default.
- W2772060643 cites W2023260280 @default.
- W2772060643 cites W2027664346 @default.
- W2772060643 cites W2029058626 @default.
- W2772060643 cites W2029369612 @default.
- W2772060643 cites W2030787754 @default.
- W2772060643 cites W2033278243 @default.
- W2772060643 cites W2033771698 @default.
- W2772060643 cites W2034105864 @default.
- W2772060643 cites W2036263897 @default.
- W2772060643 cites W2039035664 @default.
- W2772060643 cites W2039190382 @default.
- W2772060643 cites W2043251036 @default.
- W2772060643 cites W2044627868 @default.
- W2772060643 cites W2048661776 @default.
- W2772060643 cites W2050546552 @default.
- W2772060643 cites W2051288723 @default.
- W2772060643 cites W2052510647 @default.
- W2772060643 cites W2053190232 @default.
- W2772060643 cites W2053800188 @default.
- W2772060643 cites W2057128909 @default.
- W2772060643 cites W2063994009 @default.
- W2772060643 cites W2067469475 @default.
- W2772060643 cites W2073471396 @default.
- W2772060643 cites W2074636706 @default.
- W2772060643 cites W2080200842 @default.
- W2772060643 cites W2085372616 @default.
- W2772060643 cites W2088845807 @default.
- W2772060643 cites W2094513319 @default.
- W2772060643 cites W2098642477 @default.
- W2772060643 cites W2109494581 @default.
- W2772060643 cites W2109861965 @default.
- W2772060643 cites W2129032292 @default.
- W2772060643 cites W2137331743 @default.
- W2772060643 cites W2141914388 @default.
- W2772060643 cites W2146219284 @default.
- W2772060643 cites W2156160866 @default.
- W2772060643 cites W2158695071 @default.
- W2772060643 cites W2318940845 @default.
- W2772060643 cites W2325108445 @default.
- W2772060643 cites W2412982968 @default.
- W2772060643 cites W54080868 @default.
- W2772060643 cites W2101379454 @default.
- W2772060643 doi "https://doi.org/10.1038/s41598-017-17402-1" @default.
- W2772060643 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5725462" @default.
- W2772060643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29229934" @default.
- W2772060643 hasPublicationYear "2017" @default.
- W2772060643 type Work @default.
- W2772060643 sameAs 2772060643 @default.
- W2772060643 citedByCount "31" @default.
- W2772060643 countsByYear W27720606432018 @default.
- W2772060643 countsByYear W27720606432019 @default.
- W2772060643 countsByYear W27720606432020 @default.
- W2772060643 countsByYear W27720606432021 @default.
- W2772060643 countsByYear W27720606432022 @default.
- W2772060643 countsByYear W27720606432023 @default.
- W2772060643 crossrefType "journal-article" @default.
- W2772060643 hasAuthorship W2772060643A5022215889 @default.
- W2772060643 hasAuthorship W2772060643A5043823252 @default.
- W2772060643 hasAuthorship W2772060643A5048793396 @default.