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• W2772060764 abstract "The precise mechanisms relating type 1 diabetes (T1D) and poor glycemic control to the axis of growth hormone (GH), insulin like growth factor- I (IGF-I), and IGF binding protein-3 (IGFBP-3) remain to be definitively determined. GH resistance with low IGF-I as is frequently seen in patients with T1D is often related to portal hypoinsulization, and lack of upregulation of GH receptors. There are conflicting reports of the effect of a dysregulated GH/IGF-I axis on height in children and adolescents with T1D, as well as on chronic complications. This brief review discusses some of the interactions between the GH/IGF-I axis and T1D pathology, and vice-versa." @default.
• W2772060764 created "2017-12-22" @default.
• W2772060764 creator A5027031756 @default.
• W2772060764 creator A5044863989 @default.
• W2772060764 date "2018-02-01" @default.
• W2772060764 modified "2023-09-25" @default.
• W2772060764 title "Growth hormone and insulin-like growth factor-I axis in type 1 diabetes" @default.
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• W2772060764 doi "https://doi.org/10.1016/j.ghir.2017.12.005" @default.
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