FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772067201> ?p ?o ?g. }

• W2772067201 endingPage "402" @default.
• W2772067201 startingPage "394" @default.
• W2772067201 abstract "Neuropilin-1 (NRP1), which functions as a coreceptor for vascular endothelial growth factor (VEGF) and is implicated in vascular permeability and tumorigenesis, has been targeted by peptides that specifically bind to the VEGF-binding region on NRP1. Like natural VEGF ligands, all known peptides with NRP1-binding activity bind only through a carboxy (C)-terminal R/K-x-x-R/K sequence motif (x stands for any amino acids); this strict requirement is called the C-end rule (CendR). Here, we report immunoglobulin Fc-fused NRP1-specific peptides deviating from CendR. We screened a yeast surface-displayed Fc-fused non-CendR peptide library against NRP1 and isolated Fc-V12, wherein V12 peptide comprising 12 amino acids has a PPRV sequence at its C-terminal end. Although Fc-V12 lacked the CendR motif, it showed selective binding to the VEGF-binding region of NRP1 and triggered cellular internalization of NRP1, which resulted in enhanced extravasation into tumor tissues and tumor tissue penetration of the Fc-fused pe..." @default.
• W2772067201 created "2017-12-22" @default.
• W2772067201 creator A5007459896 @default.
• W2772067201 creator A5014472328 @default.
• W2772067201 creator A5061875704 @default.
• W2772067201 creator A5080053304 @default.
• W2772067201 date "2017-12-21" @default.
• W2772067201 modified "2023-10-12" @default.
• W2772067201 title "Immunoglobulin Fc-Fused Peptide without C-Terminal Arg or Lys Residue Augments Neuropilin-1-Dependent Tumor Vascular Permeability" @default.
• W2772067201 cites W1145304977 @default.
• W2772067201 cites W1921756464 @default.
• W2772067201 cites W1981988157 @default.
• W2772067201 cites W1989658253 @default.
• W2772067201 cites W1994573674 @default.
• W2772067201 cites W2000091530 @default.
• W2772067201 cites W2001977752 @default.
• W2772067201 cites W2007553857 @default.
• W2772067201 cites W2009753304 @default.
• W2772067201 cites W2034646933 @default.
• W2772067201 cites W2042349690 @default.
• W2772067201 cites W2055565790 @default.
• W2772067201 cites W2059486139 @default.
• W2772067201 cites W2066272725 @default.
• W2772067201 cites W2073775185 @default.
• W2772067201 cites W2080245974 @default.
• W2772067201 cites W2085141423 @default.
• W2772067201 cites W2088667001 @default.
• W2772067201 cites W2090085423 @default.
• W2772067201 cites W2101891042 @default.
• W2772067201 cites W2123647020 @default.
• W2772067201 cites W2162816784 @default.
• W2772067201 cites W2171397377 @default.
• W2772067201 cites W2298501561 @default.
• W2772067201 cites W2330883900 @default.
• W2772067201 cites W2344537312 @default.
• W2772067201 cites W2541304206 @default.
• W2772067201 cites W2613701746 @default.
• W2772067201 cites W416305268 @default.
• W2772067201 doi "https://doi.org/10.1021/acs.molpharmaceut.7b00761" @default.
• W2772067201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29232521" @default.
• W2772067201 hasPublicationYear "2017" @default.
• W2772067201 type Work @default.
• W2772067201 sameAs 2772067201 @default.
• W2772067201 citedByCount "9" @default.
• W2772067201 countsByYear W27720672012019 @default.
• W2772067201 countsByYear W27720672012020 @default.
• W2772067201 countsByYear W27720672012021 @default.
• W2772067201 countsByYear W27720672012022 @default.
• W2772067201 crossrefType "journal-article" @default.
• W2772067201 hasAuthorship W2772067201A5007459896 @default.
• W2772067201 hasAuthorship W2772067201A5014472328 @default.
• W2772067201 hasAuthorship W2772067201A5061875704 @default.
• W2772067201 hasAuthorship W2772067201A5080053304 @default.
• W2772067201 hasConcept C12554922 @default.
• W2772067201 hasConcept C153911025 @default.
• W2772067201 hasConcept C159654299 @default.
• W2772067201 hasConcept C167734588 @default.
• W2772067201 hasConcept C185592680 @default.
• W2772067201 hasConcept C203014093 @default.
• W2772067201 hasConcept C2777025900 @default.
• W2772067201 hasConcept C2779281246 @default.
• W2772067201 hasConcept C2780898057 @default.
• W2772067201 hasConcept C2781338088 @default.
• W2772067201 hasConcept C34425596 @default.
• W2772067201 hasConcept C502942594 @default.
• W2772067201 hasConcept C55493867 @default.
• W2772067201 hasConcept C86803240 @default.
• W2772067201 hasConcept C95444343 @default.
• W2772067201 hasConceptScore W2772067201C12554922 @default.
• W2772067201 hasConceptScore W2772067201C153911025 @default.
• W2772067201 hasConceptScore W2772067201C159654299 @default.
• W2772067201 hasConceptScore W2772067201C167734588 @default.
• W2772067201 hasConceptScore W2772067201C185592680 @default.
• W2772067201 hasConceptScore W2772067201C203014093 @default.
• W2772067201 hasConceptScore W2772067201C2777025900 @default.
• W2772067201 hasConceptScore W2772067201C2779281246 @default.
• W2772067201 hasConceptScore W2772067201C2780898057 @default.
• W2772067201 hasConceptScore W2772067201C2781338088 @default.
• W2772067201 hasConceptScore W2772067201C34425596 @default.
• W2772067201 hasConceptScore W2772067201C502942594 @default.
• W2772067201 hasConceptScore W2772067201C55493867 @default.
• W2772067201 hasConceptScore W2772067201C86803240 @default.
• W2772067201 hasConceptScore W2772067201C95444343 @default.
• W2772067201 hasFunder F4320322120 @default.
• W2772067201 hasIssue "2" @default.
• W2772067201 hasLocation W27720672011 @default.
• W2772067201 hasOpenAccess W2772067201 @default.
• W2772067201 hasPrimaryLocation W27720672011 @default.
• W2772067201 hasRelatedWork W2029603998 @default.
• W2772067201 hasRelatedWork W2045449545 @default.
• W2772067201 hasRelatedWork W2086819077 @default.
• W2772067201 hasRelatedWork W2133580395 @default.
• W2772067201 hasRelatedWork W2141604500 @default.
• W2772067201 hasRelatedWork W2336641236 @default.
• W2772067201 hasRelatedWork W2350580579 @default.
• W2772067201 hasRelatedWork W2390215864 @default.
• W2772067201 hasRelatedWork W2950269921 @default.
• W2772067201 hasRelatedWork W3157523411 @default.

• next