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- W2772070257 abstract "1571 Objectives We assessed the prognostic values of 18F-FDG PET/CT (PET) and 99mTc-MDP bone scintigraphy (BS) in patients with osteosarcoma treated with neoadjuvant chemotherapy (NAC) and surgery. Methods We retrospectively enrolled 57 patients with high-grade osteosarcoma treated with two cycles of NAC and surgery. All patients underwent PET and BS before and after the completion of NAC (before surgery). 18F-FDG uptake of primary tumor was measured quantitatively as the maximum SUV (SUV) and 99mTc-MDP uptake was measured as the maximum tumor-to-nontumor ratio (T/NT) before and after NAC. The percent changes of T/NT (%T/NT) and SUV (%SUV) after NAC were calculated respectively, and histological responses (good vs. poor) were assessed by examination of postsurgical specimens. We followed-up for more than 2 years for metastasis-free patients. ROC curve analyses and the Cox proportional hazard model were used to analyze whether %SUV, %TNT, and clinicopathological parameters could predict metastasis-free survival. Results Thirty of 57 patients (53%) showed good histological response. Based on ROC curve analysis, both %SUV (AUC = 0.829, p = 0.001) and %T/NT (AUC = 0.768, p -50%, and 100% and 39.5%, for the criterion of %T/NT > -30%, respectively. By using combined criterion of %SUV > -50% and %TNT > -30%, sensitivity and specificity were 85.7% and 72.1%, respectively. The 2 y- and 5 y metastasis-free survival rates of patients fulfilling this criterion (n = 24) were 58% and 49%, respectively, while those of others (n = 33) were 94% and 94%, respectively. By multivariate analysis, this combined criterion of %SUV > -50% and %TNT > -30% independently shortened metastasis-free survival (RR, 9.64; 95% CI, 1.87-49.61), while poor histological response did not (RR, 1.16; 95% CI, 0.32-4.15). Conclusions Both PET and BS are useful for predicting prognosis in osteosarcoma. By combining these two modalities, the prediction of prognosis might be improved." @default.
- W2772070257 created "2017-12-22" @default.
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- W2772070257 date "2016-05-01" @default.
- W2772070257 modified "2023-09-25" @default.
- W2772070257 title "The Combination of 18F-FDG PET/CT and 99mTc-MDP Bone Scintigraphy for the Prediction of Prognosis of Patients with Osteosarcoma." @default.
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