FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772077934> ?p ?o ?g. }

• W2772077934 endingPage "514" @default.
• W2772077934 startingPage "500" @default.
• W2772077934 abstract "Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the effects of pristimerin on CSCs as well as on the other malignant cells (MCF-7 and MDA-MB-231) of breast cancer. The anti-growth activity of pristimerin against MCF-7 and MCF-7s (cancer stem cell enriched population) cells was investigated by real time viability monitorization (xCELLigence System®) and ATP assay, respectively. Mode of cell death was evaluated using electron and fluorescence microscopies, western blotting (autophagy, apoptosis and ER-stress related markers) and flow cytometry (annexin-V staining, caspase 3/7 activity, BCL-2 and PI3K expressions). Pristimerin showed an anti-growth effect on cancer cells and cancer stem cells with IC50 values ranging at 0.38–1.75 μM. It inhibited sphere formation at relatively lower doses (<1.56 μM). Apoptosis was induced in MCF-7 and MCF-7s cells. In addition, extensive cytoplasmic vacuolation was observed, implying an incompleted autophagy as evidenced by the increase of autophagy-related proteins (p62 and LC3-II) with an unfolded protein response (UPR). Pristimerin inhibited the growth of MCF-7 and MDA-MB-231-originated xenografts in NOD.CB17-Prkdcscid/J mice. In mice, apoptosis was further confirmed by cleavage of PARP, activation of caspase 3 and/or 7 and TUNEL staining. Taken together, pristimerin shows cytotoxic activity on breast cancer both in vitro and in vivo. It seems to represent a robust promising agent for the treatment of breast cancer. Pristimerin’s itself or synthetic novel derivatives should be taken into consideration for novel potent anticancer agent(s)." @default.
• W2772077934 created "2017-12-22" @default.
• W2772077934 creator A5002718149 @default.
• W2772077934 creator A5010089994 @default.
• W2772077934 creator A5022736757 @default.
• W2772077934 creator A5022844446 @default.
• W2772077934 creator A5033075221 @default.
• W2772077934 creator A5033637880 @default.
• W2772077934 creator A5035603928 @default.
• W2772077934 creator A5040193650 @default.
• W2772077934 creator A5043651452 @default.
• W2772077934 creator A5044146410 @default.
• W2772077934 creator A5047890987 @default.
• W2772077934 creator A5054229275 @default.
• W2772077934 creator A5068240361 @default.
• W2772077934 creator A5068335237 @default.
• W2772077934 creator A5071370272 @default.
• W2772077934 creator A5088315023 @default.
• W2772077934 creator A5089106577 @default.
• W2772077934 creator A5089162429 @default.
• W2772077934 date "2018-03-01" @default.
• W2772077934 modified "2023-10-01" @default.
• W2772077934 title "A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer" @default.
• W2772077934 cites W1508661542 @default.
• W2772077934 cites W1518640128 @default.
• W2772077934 cites W1559013650 @default.
• W2772077934 cites W1750541550 @default.
• W2772077934 cites W1811113179 @default.
• W2772077934 cites W1966542709 @default.
• W2772077934 cites W1975133676 @default.
• W2772077934 cites W1976531450 @default.
• W2772077934 cites W1976856568 @default.
• W2772077934 cites W1977066096 @default.
• W2772077934 cites W1985405863 @default.
• W2772077934 cites W1993842564 @default.
• W2772077934 cites W2001399725 @default.
• W2772077934 cites W2002207827 @default.
• W2772077934 cites W2003413995 @default.
• W2772077934 cites W2004280628 @default.
• W2772077934 cites W2007145040 @default.
• W2772077934 cites W2009295603 @default.
• W2772077934 cites W2012071567 @default.
• W2772077934 cites W2023529679 @default.
• W2772077934 cites W2029715013 @default.
• W2772077934 cites W2029958721 @default.
• W2772077934 cites W2032324982 @default.
• W2772077934 cites W2040595737 @default.
• W2772077934 cites W2045563337 @default.
• W2772077934 cites W2050355668 @default.
• W2772077934 cites W2061608512 @default.
• W2772077934 cites W2068140221 @default.
• W2772077934 cites W2071742078 @default.
• W2772077934 cites W2085046755 @default.
• W2772077934 cites W2088035579 @default.
• W2772077934 cites W2090362418 @default.
• W2772077934 cites W2092956992 @default.
• W2772077934 cites W2093500494 @default.
• W2772077934 cites W2094079572 @default.
• W2772077934 cites W2094670023 @default.
• W2772077934 cites W2095133247 @default.
• W2772077934 cites W2106230865 @default.
• W2772077934 cites W2111986800 @default.
• W2772077934 cites W2113423279 @default.
• W2772077934 cites W2117515893 @default.
• W2772077934 cites W2122403976 @default.
• W2772077934 cites W2127916470 @default.
• W2772077934 cites W2133355328 @default.
• W2772077934 cites W2133644385 @default.
• W2772077934 cites W2137395552 @default.
• W2772077934 cites W2255395527 @default.
• W2772077934 cites W2287785450 @default.
• W2772077934 cites W2297893913 @default.
• W2772077934 cites W2328651665 @default.
• W2772077934 cites W2333914527 @default.
• W2772077934 cites W2346086236 @default.
• W2772077934 cites W2428019472 @default.
• W2772077934 cites W2520852005 @default.
• W2772077934 cites W2521885592 @default.
• W2772077934 cites W2953306978 @default.
• W2772077934 cites W367142312 @default.
• W2772077934 cites W983514923 @default.
• W2772077934 doi "https://doi.org/10.1016/j.phrs.2017.11.027" @default.
• W2772077934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29197639" @default.
• W2772077934 hasPublicationYear "2018" @default.
• W2772077934 type Work @default.
• W2772077934 sameAs 2772077934 @default.
• W2772077934 citedByCount "60" @default.
• W2772077934 countsByYear W27720779342017 @default.
• W2772077934 countsByYear W27720779342018 @default.
• W2772077934 countsByYear W27720779342019 @default.
• W2772077934 countsByYear W27720779342020 @default.
• W2772077934 countsByYear W27720779342021 @default.
• W2772077934 countsByYear W27720779342022 @default.
• W2772077934 countsByYear W27720779342023 @default.
• W2772077934 crossrefType "journal-article" @default.
• W2772077934 hasAuthorship W2772077934A5002718149 @default.
• W2772077934 hasAuthorship W2772077934A5010089994 @default.
• W2772077934 hasAuthorship W2772077934A5022736757 @default.

• next