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- W2772078591 abstract "A. Hyperdynamic circulation with decreased systemic vascular resistance (SVR) is common in recipients of liver transplantation (LT) and usually aggravated after reperfusion. Vasopressor was used to maintain adequate mean blood pressure (MBP) and tapered as MBP was increased. We investigated the factors associated with delayed weaning of vasopressor after reperfusion in LT. B. With approval of IRB, 361 LT recipients from October 2010 to July 2013 were retrospectively reviewed. We used vasopressor when MBP < 70mmHg and SVR < 600 dyne · s · cm-5. High dose vasopressor therapy was defined as a requirement of ≥ 0.2 mcg/kg/min of norepinephrine equivalent (calculated by summing norepinephrine equivalent infusion rates of all vasopressors). Recipients who weaned the vasopressor down to 0.03mcg/kg/min within 24 hours after reperfusion were early weaning group (E group), and others were late weaning group (L group). Various clinical factors were compared between two groups. C.Ninety-six recipients required high vasopressor therapy after reperfusion, and early tapering of vasopressor occurred in 51% (49/96). Two groups were not different in age, comorbidity (hypertension, diabetes, and ascites), preoperative medications (angiotensin receptor blocker, calcium channel blocker, beta blocker, and diuretics), preoperative hematocrit, sodium, and graft characteristics (type, age, gender ratio, cold ischemic time, warm ischemic time, macrosteatosis, microsteatosis, and graft-recipient weight ratio). However, female gender ratio (p=0.038), MELD score (p=0.025), preoperative lactate (p=0.027), intraoperative RBC transfusion (p < 0.001) were higher, while preoperative albumin (p=0.028) was lower in L group than E group. D. Female gender, poor preoperative recipient condition (high MELD score, high lactate, and low albumin), and intraoperative RBC transfusion increased the prevalence of late weaning of vasopressor after reperfusion of graft in LT." @default.
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- W2772078591 date "2014-07-01" @default.
- W2772078591 modified "2023-10-17" @default.
- W2772078591 title "Predictive Factors of Vasopressor Weaning After Reperfusion in Liver Transplantation." @default.
- W2772078591 doi "https://doi.org/10.1097/00007890-201407151-02709" @default.
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