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• W2772080050 abstract "Despite advances in early detection and the understanding of the molecular bases of breast cancer biology, the real challenges in therapeutics lie in detecting the disease progression and relapse. Resistance to therapy is not only common but expected. Multidisciplinary joint efforts are required in making necessary progress with breast cancer treatment. With the recent advances in multiplex genotyping and high-throughput genomic sequencing technologies, breast cancer is now considered as a group of diseases characterised by varied clonal evolution with different molecular and cellular mechanisms which drive tumour initiation, proliferation and progression with underlying resistance. Using the liquid biopsy, attempt to discover clinical molecular biomarkers are progressing rapidly as we begin to understand the complex mechanisms that transform a normal cell to a cancer cell and leading to a resistant cell. One of the examples of these molecularly targeted biomarker therapies in HER2/neu-positive breast cancer is HER2/neu blockage. Following endocrine therapy, the occurrence of secondary resistance, such as ESR1 mutations, poses a significant challenge. Drugs like lapatinib may be effective to overcome EGFR therapy resistance but it needs to be established yet. FGFR target therapy may also be interesting, but still little is known about its clinical significance. Analysis of liquid biopsy has the potential to change the clinical practice by exploiting the blood rather than the tissue as a source of underlying mechanisms. Multiple clinical studies on liquid biopsies have already been used to monitor disease response and track the emergence of drug resistance. With the computing power, the sheer amounts of data generated through sequencing and other technologies are exponentially increasing with each day. This also creates a gap between the possibilities and which can be practiced clinically. Artificial intelligence algorithms could help to determine what type of resistance a patient attains with the disease relapse and whether a tumor is a new cancer or a recurrence of previous disease, all of which has implications for treatment. Targeted therapeutics including EGFR and FGFR amplifications have been detected and associated with endocrine resistance in hormone receptor-positive breast cancers have been discussed in the previous chapters of this book. In this chapter, we present the potential of circulating tumour DNA in improving and understanding the possible resistance mechanisms through cancer genomics and integrating with artificial intelligence." @default.
• W2772080050 created "2017-12-22" @default.
• W2772080050 creator A5007240978 @default.
• W2772080050 creator A5079710831 @default.
• W2772080050 date "2017-01-01" @default.
• W2772080050 modified "2023-09-27" @default.
• W2772080050 title "Future Paradigm of Breast Cancer Resistance and Treatment" @default.
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