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• W2772087483 endingPage "310" @default.
• W2772087483 startingPage "298" @default.
• W2772087483 abstract "Autophagy is a lysosomal degradation pathway that is critical to maintaining neuronal homeostasis and viability. Autophagy sequesters damaged and aged cellular components from the intracellular environment, and shuttles these diverse macromolecules to lysosomes for destruction. This active surveillance of the quality of the cytoplasm and organelles is essential in neurons to sustain their long-term functionality and viability. Indeed, defective autophagy is linked to neurodevelopmental abnormalities and neurodegeneration in mammals. Here, we review the mechanisms of autophagy in neurons and functional roles for autophagy in neuronal homeostasis. We focus on the compartment-specific dynamics of autophagy in neurons, and how autophagy might perform non-canonical functions critical for neurons. We suggest the existence of multiple populations of autophagosomes with compartment-specific functions important for neural activity and function. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 298-310, 2018." @default.
• W2772087483 created "2017-12-22" @default.
• W2772087483 creator A5034016595 @default.
• W2772087483 creator A5081960620 @default.
• W2772087483 date "2017-12-15" @default.
• W2772087483 modified "2023-10-17" @default.
• W2772087483 title "Compartment-specific dynamics and functions of autophagy in neurons" @default.
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