Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772093144> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2772093144 abstract "C. nutans (Burm. f.) Lindau is a shrub that is commonly found in South East Asia, particularly in Malaysia, Thailand and Indonesia. This plant has diverse and potential medicinal uses in traditional herbal medicine for treating many diseases which include skin rashes. Skin rash is one of the symptoms that primarily occur in people with allergies. Till date, there has been no scientific evidence to support this traditional use of C. nutans as well as its potential of possessing anti-allergic properties. IgE and mast cells play an important role in the pathogenesis of allergy. Upon cross-linking of allergen to IgE antibodies bound to FcεRI on mast cells, pro-inflammatory mediators will be released as a result of degranulation. The release of pro-inflammatory mediators by mast cells activated by allergen in the skin causes large, itchy, red swellings of the skin. This study aimed to identify the most active C. nutans extract in inhibiting in vitro IgE-mast cell degranulation. Rat basophilic leukaemic cells (RBL-2H3) were pre-sensitised with IgE, pre-treated with C. nutans ethanolic (100%, 70% and 50%) or aqueous extracts and challenged with dinitrophenyl-bovine serum albumin (DNP-BSA) accordingly to analyse the release of β-hexosaminidase, histamine, interleukin (IL)-4 and tumour necrosis factor (TNF)-α. It was found that C. nutans aqueous extract was the most active extract compared to the ethanolic extracts as it was able to inhibit the release of β-hexosaminidase and histamine at concentrations of 5 mg/ml and above." @default.
- W2772093144 created "2017-12-22" @default.
- W2772093144 creator A5001095437 @default.
- W2772093144 creator A5018364978 @default.
- W2772093144 creator A5026996000 @default.
- W2772093144 creator A5029782119 @default.
- W2772093144 creator A5033625787 @default.
- W2772093144 creator A5058116134 @default.
- W2772093144 creator A5065580449 @default.
- W2772093144 creator A5070788532 @default.
- W2772093144 creator A5073971958 @default.
- W2772093144 date "2017-11-06" @default.
- W2772093144 modified "2023-09-27" @default.
- W2772093144 title "Clinacanthus nutans Aqueous Extract But Not Ethanolic Extract Inhibits the Release of Preformed Mediators in In Vitro Model of IgE-Mediated Mast Cell Degranulation" @default.
- W2772093144 doi "https://doi.org/10.29269/pbb2017.v1i2.6" @default.
- W2772093144 hasPublicationYear "2017" @default.
- W2772093144 type Work @default.
- W2772093144 sameAs 2772093144 @default.
- W2772093144 citedByCount "1" @default.
- W2772093144 countsByYear W27720931442019 @default.
- W2772093144 crossrefType "journal-article" @default.
- W2772093144 hasAuthorship W2772093144A5001095437 @default.
- W2772093144 hasAuthorship W2772093144A5018364978 @default.
- W2772093144 hasAuthorship W2772093144A5026996000 @default.
- W2772093144 hasAuthorship W2772093144A5029782119 @default.
- W2772093144 hasAuthorship W2772093144A5033625787 @default.
- W2772093144 hasAuthorship W2772093144A5058116134 @default.
- W2772093144 hasAuthorship W2772093144A5065580449 @default.
- W2772093144 hasAuthorship W2772093144A5070788532 @default.
- W2772093144 hasAuthorship W2772093144A5073971958 @default.
- W2772093144 hasConcept C1122143 @default.
- W2772093144 hasConcept C141105273 @default.
- W2772093144 hasConcept C159654299 @default.
- W2772093144 hasConcept C170493617 @default.
- W2772093144 hasConcept C185592680 @default.
- W2772093144 hasConcept C202751555 @default.
- W2772093144 hasConcept C203014093 @default.
- W2772093144 hasConcept C207480886 @default.
- W2772093144 hasConcept C2779726688 @default.
- W2772093144 hasConcept C49802076 @default.
- W2772093144 hasConcept C55493867 @default.
- W2772093144 hasConcept C556039675 @default.
- W2772093144 hasConcept C71924100 @default.
- W2772093144 hasConcept C86803240 @default.
- W2772093144 hasConcept C98274493 @default.
- W2772093144 hasConceptScore W2772093144C1122143 @default.
- W2772093144 hasConceptScore W2772093144C141105273 @default.
- W2772093144 hasConceptScore W2772093144C159654299 @default.
- W2772093144 hasConceptScore W2772093144C170493617 @default.
- W2772093144 hasConceptScore W2772093144C185592680 @default.
- W2772093144 hasConceptScore W2772093144C202751555 @default.
- W2772093144 hasConceptScore W2772093144C203014093 @default.
- W2772093144 hasConceptScore W2772093144C207480886 @default.
- W2772093144 hasConceptScore W2772093144C2779726688 @default.
- W2772093144 hasConceptScore W2772093144C49802076 @default.
- W2772093144 hasConceptScore W2772093144C55493867 @default.
- W2772093144 hasConceptScore W2772093144C556039675 @default.
- W2772093144 hasConceptScore W2772093144C71924100 @default.
- W2772093144 hasConceptScore W2772093144C86803240 @default.
- W2772093144 hasConceptScore W2772093144C98274493 @default.
- W2772093144 hasLocation W27720931441 @default.
- W2772093144 hasOpenAccess W2772093144 @default.
- W2772093144 hasPrimaryLocation W27720931441 @default.
- W2772093144 hasRelatedWork W122716635 @default.
- W2772093144 hasRelatedWork W1603220735 @default.
- W2772093144 hasRelatedWork W1972217642 @default.
- W2772093144 hasRelatedWork W1978257177 @default.
- W2772093144 hasRelatedWork W2054627038 @default.
- W2772093144 hasRelatedWork W2073415661 @default.
- W2772093144 hasRelatedWork W2095212771 @default.
- W2772093144 hasRelatedWork W2117155382 @default.
- W2772093144 hasRelatedWork W2333768160 @default.
- W2772093144 hasRelatedWork W2392880551 @default.
- W2772093144 hasRelatedWork W2604214581 @default.
- W2772093144 hasRelatedWork W2793661600 @default.
- W2772093144 hasRelatedWork W2899420635 @default.
- W2772093144 hasRelatedWork W2914384200 @default.
- W2772093144 hasRelatedWork W2919068483 @default.
- W2772093144 hasRelatedWork W2948378460 @default.
- W2772093144 hasRelatedWork W2978175058 @default.
- W2772093144 hasRelatedWork W2995245895 @default.
- W2772093144 hasRelatedWork W84805843 @default.
- W2772093144 hasRelatedWork W3086694204 @default.
- W2772093144 isParatext "false" @default.
- W2772093144 isRetracted "false" @default.
- W2772093144 magId "2772093144" @default.
- W2772093144 workType "article" @default.