FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772123654> ?p ?o ?g. }

• W2772123654 abstract "Sodium butyrate (SB), a short chain (C‑4) saturated fatty acid, is present in the human bowel at increased concentrations (~2 mM) as a food metabolite. It has been demonstrated that SB exerts an anti‑tumor effect as a histone deacetylase inhibitor; however, its precise mechanism of action remains to be elucidated. The present study focused on the mechanisms underlying the effects of SB on glioblastoma (GB) cell proliferation, motility and invasion. In human GB A172 cells, flow cytometry and a Boyden chamber assay demonstrated that physiological concentrations of SB (0.25‑4.00 mM) dose‑dependently inhibited cell proliferation and invasion. SB also affected cellular morphology, with increases in cell area and the number of focal adhesions observed. However, the phosphorylation (Y397 site) of focal adhesion kinase (FAK) was increased, while that of myosin light chain (S19 site) was unaltered. All of these SB‑induced effects were reversible and attenuated following SB withdrawal. In addition, A172 cells treated with SB exhibited positivity for senescence‑associated (SA) β‑galactosidase (gal) staining and elevated protein expression of p53 and p21 in a time‑ and dose‑dependent manner, whereas the expression of p21 mRNA decreased. Knockdown of p21 expression using small interfering RNA reversed the inhibition of cell growth inhibition and positivity for SA β‑gal staining, but did not reverse the inhibition of cell motility and enhanced phosphorylation of FAK. This suggests that cells require p21 to induce senescence but not for SB‑mediated decreased motility. Therefore, the current study demonstrated that SB inhibits GB cell proliferation, induces cells to senesce and inhibits tumor cell invasion, indicating that it may be developed as a novel therapeutic strategy to treat GB." @default.
• W2772123654 created "2017-12-22" @default.
• W2772123654 creator A5010146375 @default.
• W2772123654 creator A5023065104 @default.
• W2772123654 creator A5038715654 @default.
• W2772123654 date "2017-12-05" @default.
• W2772123654 modified "2023-09-30" @default.
• W2772123654 title "Sodium butyrate induces senescence and inhibits the invasiveness of glioblastoma cells" @default.
• W2772123654 cites W1579963067 @default.
• W2772123654 cites W1931140155 @default.
• W2772123654 cites W1995133050 @default.
• W2772123654 cites W1996719655 @default.
• W2772123654 cites W1999670730 @default.
• W2772123654 cites W2016507693 @default.
• W2772123654 cites W2038195711 @default.
• W2772123654 cites W2038863497 @default.
• W2772123654 cites W2075176935 @default.
• W2772123654 cites W2077482758 @default.
• W2772123654 cites W2091767823 @default.
• W2772123654 cites W2096287682 @default.
• W2772123654 cites W2102867120 @default.
• W2772123654 cites W2143098655 @default.
• W2772123654 cites W2158681922 @default.
• W2772123654 cites W2165871546 @default.
• W2772123654 cites W2167920040 @default.
• W2772123654 cites W2202164295 @default.
• W2772123654 cites W2288156681 @default.
• W2772123654 cites W2375169070 @default.
• W2772123654 cites W2410836759 @default.
• W2772123654 cites W2531634073 @default.
• W2772123654 cites W2538948871 @default.
• W2772123654 cites W2558754297 @default.
• W2772123654 cites W2592290961 @default.
• W2772123654 cites W2594920895 @default.
• W2772123654 doi "https://doi.org/10.3892/ol.2017.7518" @default.
• W2772123654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5776921" @default.
• W2772123654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29434841" @default.
• W2772123654 hasPublicationYear "2017" @default.
• W2772123654 type Work @default.
• W2772123654 sameAs 2772123654 @default.
• W2772123654 citedByCount "11" @default.
• W2772123654 countsByYear W27721236542019 @default.
• W2772123654 countsByYear W27721236542020 @default.
• W2772123654 countsByYear W27721236542021 @default.
• W2772123654 countsByYear W27721236542022 @default.
• W2772123654 countsByYear W27721236542023 @default.
• W2772123654 crossrefType "journal-article" @default.
• W2772123654 hasAuthorship W2772123654A5010146375 @default.
• W2772123654 hasAuthorship W2772123654A5023065104 @default.
• W2772123654 hasAuthorship W2772123654A5038715654 @default.
• W2772123654 hasBestOaLocation W27721236541 @default.
• W2772123654 hasConcept C100544194 @default.
• W2772123654 hasConcept C11960822 @default.
• W2772123654 hasConcept C1491633281 @default.
• W2772123654 hasConcept C151166631 @default.
• W2772123654 hasConcept C153911025 @default.
• W2772123654 hasConcept C185592680 @default.
• W2772123654 hasConcept C22615655 @default.
• W2772123654 hasConcept C2776979534 @default.
• W2772123654 hasConcept C2778942008 @default.
• W2772123654 hasConcept C29537977 @default.
• W2772123654 hasConcept C54009773 @default.
• W2772123654 hasConcept C54355233 @default.
• W2772123654 hasConcept C553184892 @default.
• W2772123654 hasConcept C55493867 @default.
• W2772123654 hasConcept C58207958 @default.
• W2772123654 hasConcept C62112901 @default.
• W2772123654 hasConcept C81885089 @default.
• W2772123654 hasConcept C86803240 @default.
• W2772123654 hasConcept C95444343 @default.
• W2772123654 hasConceptScore W2772123654C100544194 @default.
• W2772123654 hasConceptScore W2772123654C11960822 @default.
• W2772123654 hasConceptScore W2772123654C1491633281 @default.
• W2772123654 hasConceptScore W2772123654C151166631 @default.
• W2772123654 hasConceptScore W2772123654C153911025 @default.
• W2772123654 hasConceptScore W2772123654C185592680 @default.
• W2772123654 hasConceptScore W2772123654C22615655 @default.
• W2772123654 hasConceptScore W2772123654C2776979534 @default.
• W2772123654 hasConceptScore W2772123654C2778942008 @default.
• W2772123654 hasConceptScore W2772123654C29537977 @default.
• W2772123654 hasConceptScore W2772123654C54009773 @default.
• W2772123654 hasConceptScore W2772123654C54355233 @default.
• W2772123654 hasConceptScore W2772123654C553184892 @default.
• W2772123654 hasConceptScore W2772123654C55493867 @default.
• W2772123654 hasConceptScore W2772123654C58207958 @default.
• W2772123654 hasConceptScore W2772123654C62112901 @default.
• W2772123654 hasConceptScore W2772123654C81885089 @default.
• W2772123654 hasConceptScore W2772123654C86803240 @default.
• W2772123654 hasConceptScore W2772123654C95444343 @default.
• W2772123654 hasLocation W27721236541 @default.
• W2772123654 hasLocation W27721236542 @default.
• W2772123654 hasLocation W27721236543 @default.
• W2772123654 hasLocation W27721236544 @default.
• W2772123654 hasOpenAccess W2772123654 @default.
• W2772123654 hasPrimaryLocation W27721236541 @default.
• W2772123654 hasRelatedWork W2032209516 @default.
• W2772123654 hasRelatedWork W2355897695 @default.
• W2772123654 hasRelatedWork W2356093969 @default.
• W2772123654 hasRelatedWork W2356448472 @default.
• W2772123654 hasRelatedWork W2374592133 @default.

• next