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- W2772165132 startingPage "392" @default.
- W2772165132 abstract "Increased access to highly active antiretroviral therapy (HAART) by human immunodeficiency virus postive (HIV+) individuals has become a reality worldwide. In Brazil, HAART currently reaches over half of HIV-infected subjects. In the context of a remarkable HIV-1 genetic variability, highly related variants, called quasispecies, are generated. HIV quasispecies generated during infection can influence virus persistence and pathogenicity, representing a challenge to treatment. However, the clinical relevance of minority quasispecies is still uncertain. In this study, we have determined the archived proviral sequences, viral subtype and drug resistance mutations from a cohort of HIV+ patients with undetectable viral load undergoing HAART as first-line therapy using next-generation sequencing for near full-length virus genome (NFLG) assembly. HIV-1 consensus sequences representing NFLG were obtained for eleven patients, while for another twelve varying genome coverage rates were obtained. Phylogenetic analysis showed the predominance of subtype B (83%; 19/23). Considering the minority variants, 18 patients carried archived virus harboring at least one mutation conferring antiretroviral resistance; for six patients, the mutations correlated with the current ARVs used. These data highlight the importance of monitoring HIV minority drug resistant variants and their clinical impact, to guide future regimen switches and improve HIV treatment success." @default.
- W2772165132 created "2017-12-22" @default.
- W2772165132 creator A5000173153 @default.
- W2772165132 creator A5014098853 @default.
- W2772165132 creator A5041002029 @default.
- W2772165132 creator A5041056329 @default.
- W2772165132 creator A5049457660 @default.
- W2772165132 creator A5055130101 @default.
- W2772165132 creator A5076761658 @default.
- W2772165132 creator A5077584941 @default.
- W2772165132 date "2017-12-19" @default.
- W2772165132 modified "2023-10-16" @default.
- W2772165132 title "Characterization of HIV-1 Near Full-Length Proviral Genome Quasispecies from Patients with Undetectable Viral Load Undergoing First-Line HAART Therapy" @default.
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