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- W2772206781 abstract "Endocannabinoids have emerged as versatile modulators of synaptic transmission and can act as retrograde neurotransmitters. As they cannot be stored in synaptic vesicles, endocannabinoid signalling is believed to start “on-demand”, via a stimulus-dependent synthesis from membranous precursors at the postsynaptic site. After synthesis, endocannabinoids bind presynaptically to cannabinoid type 1 receptors (CB1Rs), leading to a short- or long-term suppression of neurotransmitter release. CB1Rs are present in a plethora of different synaptic connections in the brain. Electrophysiological and behavioral analyses of mutant mice lacking CB1Rs, and of pharmacologically treated rodents with CB1R antagonists, have established multiple functions of endocannabinoids as modulators of memory processing." @default.
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- W2772206781 date "2017-01-01" @default.
- W2772206781 modified "2023-09-26" @default.
- W2772206781 title "Role of Endocannabinoids in Synaptic Plasticity and Memory ☆" @default.
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- W2772206781 doi "https://doi.org/10.1016/b978-0-12-809324-5.02289-6" @default.
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