Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772224325> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2772224325 abstract "Introduction: Left atrial (LA) volume is associated with incident cardiovascular disease (CVD) in studies involving referral populations. Fewer studies have examined the association of measures of LA function with CVD events in community-based cohorts without clinically apparent disease. Methods: We investigated the relations and predictive value of LA volume index (LAVI=LA volume/body surface area), LA emptying fraction (LAEF= [Max LA Volume - Min LA Volume]/Max LA Volume) and LA function index (LAFI=[LAEFxLV outflow tract velocity time integral]/LAVI) with CVD events (coronary heart disease, stroke, heart failure) in a population-based cohort study of American Indians with high prevalences of obesity and diabetes. We excluded participants with clinical CVD, atrial fibrillation and Echo valvular disease, leaving 2,753 participants for analysis (age 59±8 years, 65% women). Stored Echos were reviewed in a random subset of 2,128 participants, 1,899 of whom had measurable maximal and minimal LA volumes. LA volume was measured using the modified biplane area-length method. Results: During median f/u of 13.5 yrs, 595 CVD events occurred. After adjustment for age, sex, BMI, systolic BP, hypertensive medication, diabetes, smoking, total and HDL cholesterol, eGFR, albuminuria, CRP, and LA diameter, LAVI (HR per SD increment 1.12, 95% CI 1.01-1.23) and LAFI (HR per SD decrement 1.19 [1.08-1.32]) were significantly associated with CVD events, but LAEF was not (HR per SD decrement 1.09 [0.99-1.19]). These risk estimates were unchanged after additional adjustment for LV mass index, LV regional or global function, transmitral E/A, and MAC. LAVI and LAFI modestly improved risk prediction when added to a clinical model (c-index 0.767 and 0.768, respectively, vs. 0.761), as well as a model containing clinical and other Echo predictors (c-index 0.776 and 0.777 vs. 0.771). Addition of LAFI to LAVI in the latter model, however, did not further improve prediction (c-index 0.777 vs. 0.776). Conclusion: In this sample of American Indians, LAVI and LAFI were associated with CVD independent of clinical risk factors, LA diameter, and other Echo predictors. Both measures improved risk prediction, although there was no evidence of incremental value when LAFI was added to LAVI." @default.
- W2772224325 created "2017-12-22" @default.
- W2772224325 creator A5018436834 @default.
- W2772224325 creator A5026874493 @default.
- W2772224325 creator A5031475597 @default.
- W2772224325 creator A5037070343 @default.
- W2772224325 creator A5038725090 @default.
- W2772224325 creator A5039797196 @default.
- W2772224325 creator A5052501142 @default.
- W2772224325 creator A5070031053 @default.
- W2772224325 creator A5073443955 @default.
- W2772224325 date "2016-11-11" @default.
- W2772224325 modified "2023-09-26" @default.
- W2772224325 title "Abstract 16011: Prospective Associations of Left Atrial Size and Function With Cardiovascular Disease in American Indians: The Strong Heart Study" @default.
- W2772224325 hasPublicationYear "2016" @default.
- W2772224325 type Work @default.
- W2772224325 sameAs 2772224325 @default.
- W2772224325 citedByCount "0" @default.
- W2772224325 crossrefType "journal-article" @default.
- W2772224325 hasAuthorship W2772224325A5018436834 @default.
- W2772224325 hasAuthorship W2772224325A5026874493 @default.
- W2772224325 hasAuthorship W2772224325A5031475597 @default.
- W2772224325 hasAuthorship W2772224325A5037070343 @default.
- W2772224325 hasAuthorship W2772224325A5038725090 @default.
- W2772224325 hasAuthorship W2772224325A5039797196 @default.
- W2772224325 hasAuthorship W2772224325A5052501142 @default.
- W2772224325 hasAuthorship W2772224325A5070031053 @default.
- W2772224325 hasAuthorship W2772224325A5073443955 @default.
- W2772224325 hasConcept C126322002 @default.
- W2772224325 hasConcept C134018914 @default.
- W2772224325 hasConcept C164705383 @default.
- W2772224325 hasConcept C188816634 @default.
- W2772224325 hasConcept C2777501473 @default.
- W2772224325 hasConcept C2778198053 @default.
- W2772224325 hasConcept C2779161974 @default.
- W2772224325 hasConcept C2780221984 @default.
- W2772224325 hasConcept C2908647359 @default.
- W2772224325 hasConcept C555293320 @default.
- W2772224325 hasConcept C71924100 @default.
- W2772224325 hasConcept C78085059 @default.
- W2772224325 hasConcept C80461066 @default.
- W2772224325 hasConcept C99454951 @default.
- W2772224325 hasConceptScore W2772224325C126322002 @default.
- W2772224325 hasConceptScore W2772224325C134018914 @default.
- W2772224325 hasConceptScore W2772224325C164705383 @default.
- W2772224325 hasConceptScore W2772224325C188816634 @default.
- W2772224325 hasConceptScore W2772224325C2777501473 @default.
- W2772224325 hasConceptScore W2772224325C2778198053 @default.
- W2772224325 hasConceptScore W2772224325C2779161974 @default.
- W2772224325 hasConceptScore W2772224325C2780221984 @default.
- W2772224325 hasConceptScore W2772224325C2908647359 @default.
- W2772224325 hasConceptScore W2772224325C555293320 @default.
- W2772224325 hasConceptScore W2772224325C71924100 @default.
- W2772224325 hasConceptScore W2772224325C78085059 @default.
- W2772224325 hasConceptScore W2772224325C80461066 @default.
- W2772224325 hasConceptScore W2772224325C99454951 @default.
- W2772224325 hasLocation W27722243251 @default.
- W2772224325 hasOpenAccess W2772224325 @default.
- W2772224325 hasPrimaryLocation W27722243251 @default.
- W2772224325 hasRelatedWork W1520288558 @default.
- W2772224325 hasRelatedWork W1925678472 @default.
- W2772224325 hasRelatedWork W2088265313 @default.
- W2772224325 hasRelatedWork W2088416815 @default.
- W2772224325 hasRelatedWork W2116087154 @default.
- W2772224325 hasRelatedWork W2258716828 @default.
- W2772224325 hasRelatedWork W2297769701 @default.
- W2772224325 hasRelatedWork W2554886664 @default.
- W2772224325 hasRelatedWork W2611356926 @default.
- W2772224325 hasRelatedWork W2792443621 @default.
- W2772224325 hasRelatedWork W2794638207 @default.
- W2772224325 hasRelatedWork W2896516548 @default.
- W2772224325 hasRelatedWork W2966864283 @default.
- W2772224325 hasRelatedWork W2966957717 @default.
- W2772224325 hasRelatedWork W2980732509 @default.
- W2772224325 hasRelatedWork W3011863013 @default.
- W2772224325 hasRelatedWork W3082365656 @default.
- W2772224325 hasRelatedWork W3098095455 @default.
- W2772224325 hasRelatedWork W2421971717 @default.
- W2772224325 hasRelatedWork W2523252689 @default.
- W2772224325 hasVolume "134" @default.
- W2772224325 isParatext "false" @default.
- W2772224325 isRetracted "false" @default.
- W2772224325 magId "2772224325" @default.
- W2772224325 workType "article" @default.