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- W2772233670 endingPage "1701000" @default.
- W2772233670 startingPage "1701000" @default.
- W2772233670 abstract "Traditional cell culture and animal models utilized for preclinical drug screening have led to high attrition rates of drug candidates in clinical trials due to their low predictive power for human response. Alternative models using human cells to build in vitro biomimetics of the human body with physiologically relevant organ-organ interactions hold great potential to act as human surrogates and provide more accurate prediction of drug effects in humans. This review is a comprehensive investigation into the development of tissue-engineered human cell-based microscale multiorgan models, or multiorgan microphysiological systems for drug testing. The evolution from traditional models to macro- and microscale multiorgan systems is discussed in regards to the rationale for recent global efforts in multiorgan microphysiological systems. Current advances in integrating cell culture and on-chip analytical technologies, as well as proof-of-concept applications for these multiorgan microsystems are discussed. Major challenges for the field, such as reproducibility and physiological relevance, are discussed with comparisons of the strengths and weaknesses of various systems to solve these challenges. Conclusions focus on the current development stage of multiorgan microphysiological systems and new trends in the field." @default.
- W2772233670 created "2017-12-22" @default.
- W2772233670 creator A5008392252 @default.
- W2772233670 creator A5022104647 @default.
- W2772233670 creator A5042700800 @default.
- W2772233670 creator A5083042262 @default.
- W2772233670 date "2017-12-04" @default.
- W2772233670 modified "2023-10-17" @default.
- W2772233670 title "Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges" @default.
- W2772233670 cites W1465270826 @default.
- W2772233670 cites W1490736032 @default.
- W2772233670 cites W1569840519 @default.
- W2772233670 cites W1611067671 @default.
- W2772233670 cites W1663154925 @default.
- W2772233670 cites W1834887465 @default.
- W2772233670 cites W1839466403 @default.
- W2772233670 cites W1847104216 @default.
- W2772233670 cites W1848527143 @default.
- W2772233670 cites W1895993106 @default.
- W2772233670 cites W1897726688 @default.
- W2772233670 cites W1925085094 @default.
- W2772233670 cites W1928351941 @default.
- W2772233670 cites W1946095753 @default.
- W2772233670 cites W1964121777 @default.
- W2772233670 cites W1964891539 @default.
- W2772233670 cites W1966593985 @default.
- W2772233670 cites W1967676909 @default.
- W2772233670 cites W1968919425 @default.
- W2772233670 cites W1972298386 @default.
- W2772233670 cites W1972753010 @default.
- W2772233670 cites W1974663770 @default.
- W2772233670 cites W1976896311 @default.
- W2772233670 cites W1977039064 @default.
- W2772233670 cites W1981289417 @default.
- W2772233670 cites W1981403460 @default.
- W2772233670 cites W1982525265 @default.
- W2772233670 cites W1984201543 @default.
- W2772233670 cites W1985766023 @default.
- W2772233670 cites W1985789373 @default.
- W2772233670 cites W1986912034 @default.
- W2772233670 cites W1988343729 @default.
- W2772233670 cites W1988548218 @default.
- W2772233670 cites W1989326344 @default.
- W2772233670 cites W1990922607 @default.
- W2772233670 cites W1991273988 @default.
- W2772233670 cites W1991635000 @default.
- W2772233670 cites W1994812037 @default.
- W2772233670 cites W1995580860 @default.
- W2772233670 cites W1996765049 @default.
- W2772233670 cites W1997148600 @default.
- W2772233670 cites W1998220531 @default.
- W2772233670 cites W2000151960 @default.
- W2772233670 cites W2001726213 @default.
- W2772233670 cites W2006835321 @default.
- W2772233670 cites W2008353596 @default.
- W2772233670 cites W2008879615 @default.
- W2772233670 cites W2008985780 @default.
- W2772233670 cites W2012709951 @default.
- W2772233670 cites W2013520568 @default.
- W2772233670 cites W2015945959 @default.
- W2772233670 cites W2017921748 @default.
- W2772233670 cites W2018286352 @default.
- W2772233670 cites W2020755558 @default.
- W2772233670 cites W2021550972 @default.
- W2772233670 cites W2022941161 @default.
- W2772233670 cites W2024014455 @default.
- W2772233670 cites W2027181368 @default.
- W2772233670 cites W2029225855 @default.
- W2772233670 cites W2029807657 @default.
- W2772233670 cites W2029988210 @default.
- W2772233670 cites W2030338281 @default.
- W2772233670 cites W2030552522 @default.
- W2772233670 cites W2034540804 @default.
- W2772233670 cites W2037564218 @default.
- W2772233670 cites W2038128285 @default.
- W2772233670 cites W2038819603 @default.
- W2772233670 cites W2047245651 @default.
- W2772233670 cites W2048644480 @default.
- W2772233670 cites W2051700275 @default.
- W2772233670 cites W2051901009 @default.
- W2772233670 cites W2052637617 @default.
- W2772233670 cites W2053407380 @default.
- W2772233670 cites W2058141781 @default.
- W2772233670 cites W2060919797 @default.
- W2772233670 cites W2062331171 @default.
- W2772233670 cites W2063077960 @default.
- W2772233670 cites W2066734670 @default.
- W2772233670 cites W2070087000 @default.
- W2772233670 cites W2074103138 @default.
- W2772233670 cites W2074545908 @default.
- W2772233670 cites W2075325286 @default.
- W2772233670 cites W2075697181 @default.
- W2772233670 cites W2077265253 @default.
- W2772233670 cites W2077555199 @default.
- W2772233670 cites W2079870118 @default.
- W2772233670 cites W2080232352 @default.
- W2772233670 cites W2080242803 @default.
- W2772233670 cites W2080886982 @default.