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• W2772321106 abstract "Immune dysregulation and predisposition to malignancies are critical comorbidities in children affected with ataxia telangiectasia. In addition, these children exhibit increased toxicity to conventional cancer therapy and dose reductions have been proposed to prevent life threatening adverse effects. These modifications to the treatment regimen may result in suboptimal outcomes for these patients. Our report of 3 children with ataxia telangiectasia and cancer highlight the immense challenges in the management of these children, underlining the need for the development of novel, biological agents with reduced acute and long-term side effects in the treatment of cancers in these children." @default.
• W2772321106 created "2017-12-22" @default.
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• W2772321106 date "2018-08-01" @default.
• W2772321106 modified "2023-10-14" @default.
• W2772321106 title "Ataxia Telangiectasia and Cancer Predisposition: Challenges in Management" @default.
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• W2772321106 doi "https://doi.org/10.1097/mph.0000000000001005" @default.
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