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- W2772356474 abstract "Vascularization is critical to maintain organ function. Outgrowth and clonal expansion of endothelial cells (ECs) has been documented in vitro , however, the contribution of clonally expanding ECs to physiological versus ischemia-induced vessel growth is unknown. We analyzed the contribution of EC expansion to postnatal retina angiogenesis and ischemia-induced neovascularization after acute myocardial infarction (AMI) as well as hindlimb ischemia (HLI) using so-called Confetti mice that were crossed with the tamoxifen-inducible VE-cadherin Cre-deleter line (CDH5CreERT2/+;Rosa26Confetti/+) for genetic tracing of clonally expanding endothelial cells. Tamoxifen was injected to induce CFP-, GFP-, RFP- and YFP-fluorescent proteins in endothelial cells. In postnatal retina angiogenesis, we observed stochastic EC expansion, resulting in random distribution of fluorescence labeled EC in most sections (less than 10% of sections showed clonal expansion, n=60 sections of 8 mice). However, in pathological angiogenesis during retinopathy of prematurity (ROP) clonally expanded endothelial cells were enriched in 69% of sections (p 9 sections in each group). In aged mice that were subjected to HLI, less clonal expansion events were observed and only 11% of sections showed clonal expansion (p" @default.
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- W2772356474 date "2016-11-11" @default.
- W2772356474 modified "2023-09-26" @default.
- W2772356474 title "Abstract 16477: Revascularization After Ischemia is Mediated by Clonally Expanding Endothelial Cells and is Impaired by Aging" @default.
- W2772356474 hasPublicationYear "2016" @default.
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