FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772474522> ?p ?o ?g. }

• W2772474522 abstract "6618 Background: Despite the growing number of clinical trials conducted in Asia and the unique pt demographic and molecular profile of endemic cancers, there is still lacking of studies examining the outcomes of pts on PIT. We examined the characteristics and outcomes of pts enrolled in phase I trials in National Cancer Center Singapore (NCCS). Methods: We reviewed 296 pts enrolled in PIT from 2004-2012 to identify factors that predicted for 90-day mortality and OS. Logistic regression model and Cox proportional hazard model assessed factors associated with 90DM and OS, respectively. The discriminative ability of the RMH prognostic score (LDH, no of met sites, albumin) and the final multivariate Cox model derived in Asian pts was evaluated using Harrell’s concordance index (c-index), and that for the logistic model was based on area under ROC curve (AUC). Internal validation was performed based on simulated data via bootstrapping. Results: Median age 60 (23-85), M:F (65/35%). The commonest cancer type thoracic (56%), GI (24%), head and neck (12%). 57% pt had comorbidities, commonest diabetes (16.6%) and hepatitis B (11.1%). Median no of lines of treatment 2. 20% of pts had known mut status. 15% pts survived less than 90 days from start of trial. Median OS was 9.6 m (95CI 7.8-11.2 m). Based on the RMH prognostic model, pts with score of 0 to 1 had a superior OS (median OS = 12.9 m) compared to those with score of 2 to 3 (OS = 5.7 m) (p < 0.001). The c-index for the RMH prognostic score was 0.64. On univariate analysis, alb<35,LDH>ULN, ≥3 met sites, low BMI, ECOG>0, Na<135,plt>440, Hb<12 and ≥3 lines of chemo were negative prognostic factors. On multivariate analysis, reduced model selection techniques identified alb<35, LDH>ULN, ≥3 met sites, and ≥ 3 prior lines of chemo as independent negative predictors of OS with a bias-corrected of 0.69. For 90DM, we developed a risk normogram based on ECOG, WBC, Na and Hb as continuous predictors with bias-corrected AUC 0.78. Conclusions: We have developed a novel NCCS normogram to predict for 90DM for PIT. The RMH prognostic score can be improved upon with the addition of number of prior lines of chemotherapy, underscoring the importance of early access to phase I trials." @default.
• W2772474522 created "2017-12-22" @default.
• W2772474522 creator A5023048065 @default.
• W2772474522 creator A5028060450 @default.
• W2772474522 creator A5029453742 @default.
• W2772474522 creator A5059269204 @default.
• W2772474522 creator A5061589915 @default.
• W2772474522 creator A5073819873 @default.
• W2772474522 creator A5078632387 @default.
• W2772474522 creator A5084786332 @default.
• W2772474522 date "2013-05-20" @default.
• W2772474522 modified "2023-09-27" @default.
• W2772474522 title "Predictors of early mortality and validation of novel prognostic models in Asian patients on phase I trials (PIT): A single-center experience." @default.
• W2772474522 doi "https://doi.org/10.1200/jco.2013.31.15_suppl.6618" @default.
• W2772474522 hasPublicationYear "2013" @default.
• W2772474522 type Work @default.
• W2772474522 sameAs 2772474522 @default.
• W2772474522 citedByCount "0" @default.
• W2772474522 crossrefType "journal-article" @default.
• W2772474522 hasAuthorship W2772474522A5023048065 @default.
• W2772474522 hasAuthorship W2772474522A5028060450 @default.
• W2772474522 hasAuthorship W2772474522A5029453742 @default.
• W2772474522 hasAuthorship W2772474522A5059269204 @default.
• W2772474522 hasAuthorship W2772474522A5061589915 @default.
• W2772474522 hasAuthorship W2772474522A5073819873 @default.
• W2772474522 hasAuthorship W2772474522A5078632387 @default.
• W2772474522 hasAuthorship W2772474522A5084786332 @default.
• W2772474522 hasConcept C126322002 @default.
• W2772474522 hasConcept C143998085 @default.
• W2772474522 hasConcept C144024400 @default.
• W2772474522 hasConcept C149923435 @default.
• W2772474522 hasConcept C535046627 @default.
• W2772474522 hasConcept C71924100 @default.
• W2772474522 hasConceptScore W2772474522C126322002 @default.
• W2772474522 hasConceptScore W2772474522C143998085 @default.
• W2772474522 hasConceptScore W2772474522C144024400 @default.
• W2772474522 hasConceptScore W2772474522C149923435 @default.
• W2772474522 hasConceptScore W2772474522C535046627 @default.
• W2772474522 hasConceptScore W2772474522C71924100 @default.
• W2772474522 hasLocation W27724745221 @default.
• W2772474522 hasOpenAccess W2772474522 @default.
• W2772474522 hasPrimaryLocation W27724745221 @default.
• W2772474522 hasRelatedWork W1966776070 @default.
• W2772474522 hasRelatedWork W1967332399 @default.
• W2772474522 hasRelatedWork W1983542370 @default.
• W2772474522 hasRelatedWork W2061812258 @default.
• W2772474522 hasRelatedWork W2087375887 @default.
• W2772474522 hasRelatedWork W2100496729 @default.
• W2772474522 hasRelatedWork W2140056658 @default.
• W2772474522 hasRelatedWork W2160305793 @default.
• W2772474522 hasRelatedWork W2195026266 @default.
• W2772474522 hasRelatedWork W2267629991 @default.
• W2772474522 hasRelatedWork W2287773436 @default.
• W2772474522 hasRelatedWork W2397798220 @default.
• W2772474522 hasRelatedWork W2528618198 @default.
• W2772474522 hasRelatedWork W2893209739 @default.
• W2772474522 hasRelatedWork W2932331988 @default.
• W2772474522 hasRelatedWork W2967021462 @default.
• W2772474522 hasRelatedWork W3032078315 @default.
• W2772474522 hasRelatedWork W3118533222 @default.
• W2772474522 hasRelatedWork W3201307565 @default.
• W2772474522 hasRelatedWork W3202430098 @default.
• W2772474522 isParatext "false" @default.
• W2772474522 isRetracted "false" @default.
• W2772474522 magId "2772474522" @default.
• W2772474522 workType "article" @default.