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- W2772477256 abstract "Exposure to traumatic brain injury is a core risk factor that predisposes an individual to sporadic neurodegenerative diseases. We provide evidence that mechanical stress increases brain levels of hallmark proteins associated with neurodegeneration.Wild-type mice were exposed to multiple regimens of repetitive mild traumatic brain injury, generating a range of combinations of impact energies, frequencies, and durations of exposure. Brain concentrations of amyloid β 1-42 (Aβ1-42), total tau, and α-synuclein were measured by sandwich enzyme-linked immunosorbent assay.There was a highly significant main effect of impact energy, frequency, and duration of exposure on Aβ1-42, tau, and α-synuclein levels (P < .001), and a significant interaction between impact energy and duration of exposure for Aβ1-42 and tau (P < .001), but not for α-synuclein.Dose-dependent and cumulative influence of repetitive mild traumatic brain injury-induced mechanical stress may trigger and/or accelerate neurodegeneration by pushing protein concentration over the disease threshold." @default.
- W2772477256 created "2017-12-22" @default.
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- W2772477256 date "2017-12-12" @default.
- W2772477256 modified "2023-09-30" @default.
- W2772477256 title "Mechanical stress increases brain amyloid β, tau, and α‐synuclein concentrations in wild‐type mice" @default.
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- W2772477256 doi "https://doi.org/10.1016/j.jalz.2017.11.003" @default.
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