FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772614235> ?p ?o ?g. }

• W2772614235 abstract "Abstract Bipolar disorder is a complex neuropsychiatric disorder presenting with episodic mood disturbances. In this study we use a transcriptomic imputation approach to identify novel genes and pathways associated with bipolar disorder, as well as three diagnostically and genetically distinct subtypes. Transcriptomic imputation approaches leverage well-curated and publicly available eQTL reference panels to create gene-expression prediction models, which may then be applied to “impute” genetically regulated gene expression (GREX) in large GWAS datasets. By testing for association between phenotype and GREX, rather than genotype, we hope to identify more biologically interpretable associations, and thus elucidate more of the genetic architecture of bipolar disorder. We applied GREX prediction models for 13 brain regions (derived from CommonMind Consortium and GTEx eQTL reference panels) to 21,488 bipolar cases and 54,303 matched controls, constituting the largest transcriptomic imputation study of bipolar disorder (BPD) to date. Additionally, we analyzed three specific BPD subtypes, including 14,938 individuals with subtype 1 (BD-I), 3,543 individuals with subtype 2 (BD-II), and 1,500 individuals with schizoaffective subtype (SAB). We identified 125 gene-tissue associations with BPD, of which 53 represent independent associations after FINEMAP analysis. 29/53 associations were novel; i.e., did not lie within 1Mb of a locus identified in the recent PGC-BD GWAS. We identified 37 independent BD-I gene-tissue associations (10 novel), 2 BD-II associations, and 2 SAB associations. Our BPD, BD-I and BD-II associations were significantly more likely to be differentially expressed in post-mortem brain tissue of BPD, BD-I and BD-II cases than we might expect by chance. Together with our pathway analysis, our results support long-standing hypotheses about bipolar disorder risk, including a role for oxidative stress and mitochondrial dysfunction, the post-synaptic density, and an enrichment of circadian rhythm and clock genes within our results." @default.
• W2772614235 created "2017-12-22" @default.
• W2772614235 creator A5000877350 @default.
• W2772614235 creator A5001226865 @default.
• W2772614235 creator A5001373941 @default.
• W2772614235 creator A5002092788 @default.
• W2772614235 creator A5002321122 @default.
• W2772614235 creator A5002628021 @default.
• W2772614235 creator A5002705579 @default.
• W2772614235 creator A5003311118 @default.
• W2772614235 creator A5004322223 @default.
• W2772614235 creator A5005956415 @default.
• W2772614235 creator A5006025541 @default.
• W2772614235 creator A5006266874 @default.
• W2772614235 creator A5006966752 @default.
• W2772614235 creator A5007189110 @default.
• W2772614235 creator A5007752410 @default.
• W2772614235 creator A5007964297 @default.
• W2772614235 creator A5008103327 @default.
• W2772614235 creator A5008695173 @default.
• W2772614235 creator A5009208804 @default.
• W2772614235 creator A5009404499 @default.
• W2772614235 creator A5009579789 @default.
• W2772614235 creator A5009975789 @default.
• W2772614235 creator A5009990416 @default.
• W2772614235 creator A5010040923 @default.
• W2772614235 creator A5010158845 @default.
• W2772614235 creator A5010348708 @default.
• W2772614235 creator A5010909406 @default.
• W2772614235 creator A5011519020 @default.
• W2772614235 creator A5011846307 @default.
• W2772614235 creator A5012793922 @default.
• W2772614235 creator A5012998944 @default.
• W2772614235 creator A5013161841 @default.
• W2772614235 creator A5013242137 @default.
• W2772614235 creator A5013243306 @default.
• W2772614235 creator A5013348661 @default.
• W2772614235 creator A5014086707 @default.
• W2772614235 creator A5015327943 @default.
• W2772614235 creator A5015522761 @default.
• W2772614235 creator A5015688435 @default.
• W2772614235 creator A5016043879 @default.
• W2772614235 creator A5016103514 @default.
• W2772614235 creator A5016212527 @default.
• W2772614235 creator A5016888840 @default.
• W2772614235 creator A5017041542 @default.
• W2772614235 creator A5018081749 @default.
• W2772614235 creator A5019789097 @default.
• W2772614235 creator A5020028414 @default.
• W2772614235 creator A5020110744 @default.
• W2772614235 creator A5020215901 @default.
• W2772614235 creator A5020539457 @default.
• W2772614235 creator A5020615295 @default.
• W2772614235 creator A5020842403 @default.
• W2772614235 creator A5020856688 @default.
• W2772614235 creator A5020942575 @default.
• W2772614235 creator A5021301519 @default.
• W2772614235 creator A5021341949 @default.
• W2772614235 creator A5022855713 @default.
• W2772614235 creator A5023024313 @default.
• W2772614235 creator A5023144760 @default.
• W2772614235 creator A5023507812 @default.
• W2772614235 creator A5023657211 @default.
• W2772614235 creator A5025023257 @default.
• W2772614235 creator A5025127395 @default.
• W2772614235 creator A5025182435 @default.
• W2772614235 creator A5025278422 @default.
• W2772614235 creator A5025707647 @default.
• W2772614235 creator A5026352442 @default.
• W2772614235 creator A5026427469 @default.
• W2772614235 creator A5026517521 @default.
• W2772614235 creator A5027152344 @default.
• W2772614235 creator A5027599458 @default.
• W2772614235 creator A5027693159 @default.
• W2772614235 creator A5028348015 @default.
• W2772614235 creator A5028741548 @default.
• W2772614235 creator A5028762883 @default.
• W2772614235 creator A5029129951 @default.
• W2772614235 creator A5029360035 @default.
• W2772614235 creator A5029433360 @default.
• W2772614235 creator A5030682294 @default.
• W2772614235 creator A5031084817 @default.
• W2772614235 creator A5031613969 @default.
• W2772614235 creator A5031686292 @default.
• W2772614235 creator A5031780381 @default.
• W2772614235 creator A5032805514 @default.
• W2772614235 creator A5032997650 @default.
• W2772614235 creator A5033057812 @default.
• W2772614235 creator A5033098260 @default.
• W2772614235 creator A5033807240 @default.
• W2772614235 creator A5034065168 @default.
• W2772614235 creator A5034127226 @default.
• W2772614235 creator A5034167482 @default.
• W2772614235 creator A5034173470 @default.
• W2772614235 creator A5034381224 @default.
• W2772614235 creator A5034534740 @default.
• W2772614235 creator A5035161779 @default.
• W2772614235 creator A5035459587 @default.
• W2772614235 creator A5035834658 @default.
• W2772614235 creator A5036388273 @default.

• next