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- W2772661269 abstract "Aim: The aim of this study is to evaluate safety and effectiveness of new and repurposed TB drugs containing regimens in children and adolescents. Methods: Regimens containing bedaquiline, linezolid and clofazimine as backbone drugs were used in children and adolescents with laboratory confirmed M/XDR-TB under the following conditions: careful selection of the patients; Ethic Committee approval and informed consent obtaining; close clinical monitoring; active monitoring and management of adverse events. Results: Between September 2015 and July 2016 15 HIV-negative patients were enrolled in the study: median age 16 years (range: 10-17); 8 males; 10 XDR-TB, 5 pre-XDR-TB of whom 3 with resistance to FQ and 2 – to second line injectables; 5 with cavernous lung lesions on chest X-ray. The treatments continue with median time 11 months (range: 15-6). Adverse events (AE) were developed in all (100%) patients, though they were mild, transient and did not cause drug/regimen stop. The most frequent AE were the following: cQT prolongation, hyperuricemia, hypokalemia, liver function tests elevation, eosinophylia, headache, depression. At six months of treatment 15(100%) patients were sputum smear and culture negative, the negative status continues during further period of monitoring. Conclusion: The study preliminary results show that children and adolescents with M/XDR-TB respond favorably to new and repurposed TB drugs containing regimens confirming their safety and effectiveness." @default.
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- W2772661269 date "2017-09-01" @default.
- W2772661269 modified "2023-09-27" @default.
- W2772661269 title "New and repurposed TB drugs use in children and adolescents with M/XDR-TB" @default.
- W2772661269 doi "https://doi.org/10.1183/1393003.congress-2017.oa4853" @default.
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