FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772711580> ?p ?o ?g. }

• W2772711580 endingPage "298" @default.
• W2772711580 startingPage "297" @default.
• W2772711580 abstract "Background: The significance of the factor forkhead box (FOXP3) expression in the peripheral blood of renal transplant recipients (RTx) of extended (ECD) or standard (SCD) criteria donor kidneys is yet to be determined. Aim: To investigate the clinical significance of FOXP3 level in relation to the type of kidney donor, immunosuppressive protocol (ISS) and graft function in stable ECD RTx. Methods: Prospective, open label study with 36 stable RTx randomized according to the type of donor to receive tacrolimus (TAC; n= 19) or everolimus (EVL; n=17) based protocols combined to mycophenolate sodium, prednisone and induction therapy with basiliximab. Using qRT-PCR we measured FOXP3 expression in the peripheral blood of patients (pts) at the 3rd month after Tx. Results: Greater expression of FOXP3 was observed in recipients of ECD when compared to SCD (ECD=1.98 ± 2.8 vs SCD= 0.63 ± 0.71; p=0.02). EVL based immunosuppression (EVL= 1.49 ± 2.1 vs TAC= 0.51 ± 0.57; p=0.03) and absence of DGF post-Tx (DGF- = 1.94 ± 2.5 vs DGF+ = 0.54 ± 0.6; p=0.014) were also associated with high levels of FOXP3 expression. Cold ischemia time, acute rejection episodes and serum creatinine (sCr) at 3rd month were not associated with changes in FOXP3 expression. Multivariate logistic regression analysis showed that ECD (p= 0.025) absence of DGF (0.015) were independently associated with high levels of FOXP3. Correlation between sCr and FOXP3 was inverse in TAC treated pts and positive in those taking EVL (r= 0.74, P = 0.007). FOXP3 expression was low in kidneys with mild or no chronic lesions (IFTA score < 2) regardless the ISS. Patients treated with EVL presenting IFTA score ≥ 2 had increased expression of FOXP3 (p=NS vs TAC). Conclusions: Results suggest that recipients of ECD kidneys without having undergone DGF, treated with EVL presented an increased expression of FOXP3 in their peripheral blood. The higher FOXP3 levels associated with more chronic histological lesions may represent an anti-inflammatory response elicited by ongoing chronic allograft damage. DISCLOSURES:Abbud-Filho, M.: Grant/Research Support, Novartis. Dias, C.: Grant/Research Support, Novartis. Caldas, H.: Grant/Research Support, Novartis. Nunes, R.: Grant/Research Support, Novartis. Mazeti, C.: Grant/Research Support, Novartis. Fernandes-Charpiot, I.: Grant/Research Support, Novartis. Baptista, M.: Grant/Research Support, Novartis. Abbud-Filho, M.: Grant/Research Support, Novartis." @default.
• W2772711580 created "2017-12-22" @default.
• W2772711580 creator A5003014411 @default.
• W2772711580 creator A5004810096 @default.
• W2772711580 creator A5008881156 @default.
• W2772711580 creator A5028885225 @default.
• W2772711580 creator A5035609317 @default.
• W2772711580 creator A5039687428 @default.
• W2772711580 creator A5065879000 @default.
• W2772711580 date "2014-07-01" @default.
• W2772711580 modified "2023-10-18" @default.
• W2772711580 title "Calcineurin Free Protocol Is Associated With Increase in FOXP3 Expression in the Peripheral Blood of Recipients of Extended Criteria Donor Kidneys." @default.
• W2772711580 doi "https://doi.org/10.1097/00007890-201407151-00935" @default.
• W2772711580 hasPublicationYear "2014" @default.
• W2772711580 type Work @default.
• W2772711580 sameAs 2772711580 @default.
• W2772711580 citedByCount "0" @default.
• W2772711580 crossrefType "journal-article" @default.
• W2772711580 hasAuthorship W2772711580A5003014411 @default.
• W2772711580 hasAuthorship W2772711580A5004810096 @default.
• W2772711580 hasAuthorship W2772711580A5008881156 @default.
• W2772711580 hasAuthorship W2772711580A5028885225 @default.
• W2772711580 hasAuthorship W2772711580A5035609317 @default.
• W2772711580 hasAuthorship W2772711580A5039687428 @default.
• W2772711580 hasAuthorship W2772711580A5065879000 @default.
• W2772711580 hasConcept C126322002 @default.
• W2772711580 hasConcept C126894567 @default.
• W2772711580 hasConcept C128057223 @default.
• W2772711580 hasConcept C159641895 @default.
• W2772711580 hasConcept C203014093 @default.
• W2772711580 hasConcept C2779727006 @default.
• W2772711580 hasConcept C2780252810 @default.
• W2772711580 hasConcept C2780303639 @default.
• W2772711580 hasConcept C2780306776 @default.
• W2772711580 hasConcept C2781307858 @default.
• W2772711580 hasConcept C2911091166 @default.
• W2772711580 hasConcept C71924100 @default.
• W2772711580 hasConcept C8891405 @default.
• W2772711580 hasConcept C90924648 @default.
• W2772711580 hasConceptScore W2772711580C126322002 @default.
• W2772711580 hasConceptScore W2772711580C126894567 @default.
• W2772711580 hasConceptScore W2772711580C128057223 @default.
• W2772711580 hasConceptScore W2772711580C159641895 @default.
• W2772711580 hasConceptScore W2772711580C203014093 @default.
• W2772711580 hasConceptScore W2772711580C2779727006 @default.
• W2772711580 hasConceptScore W2772711580C2780252810 @default.
• W2772711580 hasConceptScore W2772711580C2780303639 @default.
• W2772711580 hasConceptScore W2772711580C2780306776 @default.
• W2772711580 hasConceptScore W2772711580C2781307858 @default.
• W2772711580 hasConceptScore W2772711580C2911091166 @default.
• W2772711580 hasConceptScore W2772711580C71924100 @default.
• W2772711580 hasConceptScore W2772711580C8891405 @default.
• W2772711580 hasConceptScore W2772711580C90924648 @default.
• W2772711580 hasLocation W27727115801 @default.
• W2772711580 hasOpenAccess W2772711580 @default.
• W2772711580 hasPrimaryLocation W27727115801 @default.
• W2772711580 hasRelatedWork W1486584413 @default.
• W2772711580 hasRelatedWork W2024878027 @default.
• W2772711580 hasRelatedWork W2029390475 @default.
• W2772711580 hasRelatedWork W2052365623 @default.
• W2772711580 hasRelatedWork W2087086071 @default.
• W2772711580 hasRelatedWork W2087821141 @default.
• W2772711580 hasRelatedWork W2208852829 @default.
• W2772711580 hasRelatedWork W2330154650 @default.
• W2772711580 hasRelatedWork W2361025871 @default.
• W2772711580 hasRelatedWork W4240284178 @default.
• W2772711580 hasVolume "98" @default.
• W2772711580 isParatext "false" @default.
• W2772711580 isRetracted "false" @default.
• W2772711580 magId "2772711580" @default.
• W2772711580 workType "article" @default.