FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772719847> ?p ?o ?g. }

• W2772719847 endingPage "1048" @default.
• W2772719847 startingPage "1042" @default.
• W2772719847 abstract "We report survival outcomes for patients with advanced-stage hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) treated with ⁹⁰Y radioembolization. <b>Methods:</b> With institutional review board approval, we searched our prospectively acquired database for ⁹⁰Y patients treated between 2003 and 2017. Inclusion criteria were patients who had HCC with tumor PVT. Patients with metastases were excluded. Laboratory data were collected at baseline and 1 mo after ⁹⁰Y radioembolization. Toxicity grades were reported according to the Common Terminology Criteria for Adverse Events, version 4.0, and long-term survival outcomes were reported and stratified by Child–Pugh class (CP). Overall survival was calculated using the Kaplan–Meier method. Multivariate analysis was performed using Cox proportional hazards regression. A subanalysis for patients with a high level of α-fetoprotein (AFP) (>100 ng/dL) was conducted. <b>Results:</b> In total, 185 patients with HCC PVT underwent ⁹⁰Y radioembolization. Seventy-four (40%) were CP-A, 51 (28%) were CP-B7, and 60 (32%) were ≥CP-B8. New albumin, bilirubin, and alkaline phosphatase grade 3/4 toxicities were, respectively, 3%, 10%, and 0% for CP-A; 14%, 12%, and 6% for CP-B7; and 23%, 32%, and 3% for ≥CP-B8. Median overall survival for CP-A patients was 13.3 mo (95% confidence interval [CI], 8.7–15.7 mo). CP-B7 and ≥CP-B8 patients exhibited median overall survival of 6.9 mo (95% CI, 5.3–10.1 mo) and 3.9 mo (95% CI, 2.9–5.0 mo), respectively. Significant overall survival prognosticators on univariate analysis were albumin, bilirubin, ascites, tumor size 5 cm or smaller, focality, distribution, infiltration, Eastern Cooperative Oncology Group status, AFP level, and PVT extent. Multivariate analysis showed the prognosticators of overall survival to be bilirubin, no ascites, tumor size 5 cm or smaller, solitary lesion, baseline AFP level lower than 100 ng/dL, and Eastern Cooperative Oncology Group status. Of 123 patients with a high AFP level (>100 ng/dL), 12 patients achieved restored normal AFP levels (<13 ng/dL) and exhibited median overall survival of 23.9 mo (95% CI, 20.1–124.1 mo). AFP responders at 1 mo had better overall survival than nonresponders, at 8.5 mo versus 4.8 mo (<i>P</i> = 0.018); AFP responders at 3 mo had overall survival of 13.3 mo, versus 6.9 mo for nonresponders (<i>P</i> = 0.021). <b>Conclusion:</b>⁹⁰Y radioembolization can serve as a safe and effective treatment for advanced-stage HCC patients with tumor PVT. Overall survival outcomes are affected by baseline liver function, tumor size, and AFP level." @default.
• W2772719847 created "2017-12-22" @default.
• W2772719847 creator A5011003738 @default.
• W2772719847 creator A5033464248 @default.
• W2772719847 creator A5034174603 @default.
• W2772719847 creator A5040236972 @default.
• W2772719847 creator A5044862107 @default.
• W2772719847 creator A5055996794 @default.
• W2772719847 creator A5064049623 @default.
• W2772719847 creator A5075153200 @default.
• W2772719847 creator A5086297355 @default.
• W2772719847 creator A5087536545 @default.
• W2772719847 date "2017-12-07" @default.
• W2772719847 modified "2023-10-18" @default.
• W2772719847 title "⁹⁰Y Radioembolization for Locally Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis: Long-Term Outcomes in a 185-Patient Cohort" @default.
• W2772719847 cites W1570173114 @default.
• W2772719847 cites W1971837077 @default.
• W2772719847 cites W1980760193 @default.
• W2772719847 cites W1986913991 @default.
• W2772719847 cites W1989647054 @default.
• W2772719847 cites W1994193851 @default.
• W2772719847 cites W1998417832 @default.
• W2772719847 cites W2016191890 @default.
• W2772719847 cites W2025858981 @default.
• W2772719847 cites W2034342132 @default.
• W2772719847 cites W2046000826 @default.
• W2772719847 cites W2052467396 @default.
• W2772719847 cites W2080960152 @default.
• W2772719847 cites W2081176013 @default.
• W2772719847 cites W2087571662 @default.
• W2772719847 cites W2100930626 @default.
• W2772719847 cites W2107106930 @default.
• W2772719847 cites W2109712769 @default.
• W2772719847 cites W2122639635 @default.
• W2772719847 cites W2125763116 @default.
• W2772719847 cites W2133883825 @default.
• W2772719847 cites W2138424758 @default.
• W2772719847 cites W2147172608 @default.
• W2772719847 cites W2148287035 @default.
• W2772719847 cites W2153935627 @default.
• W2772719847 cites W2158207366 @default.
• W2772719847 cites W2165336841 @default.
• W2772719847 cites W2513495305 @default.
• W2772719847 cites W2560499218 @default.
• W2772719847 cites W2606367731 @default.
• W2772719847 cites W2613310948 @default.
• W2772719847 cites W2917837889 @default.
• W2772719847 cites W2997727194 @default.
• W2772719847 cites W4297888650 @default.
• W2772719847 doi "https://doi.org/10.2967/jnumed.117.199752" @default.
• W2772719847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29217739" @default.
• W2772719847 hasPublicationYear "2017" @default.
• W2772719847 type Work @default.
• W2772719847 sameAs 2772719847 @default.
• W2772719847 citedByCount "51" @default.
• W2772719847 countsByYear W27727198472018 @default.
• W2772719847 countsByYear W27727198472019 @default.
• W2772719847 countsByYear W27727198472020 @default.
• W2772719847 countsByYear W27727198472021 @default.
• W2772719847 countsByYear W27727198472022 @default.
• W2772719847 countsByYear W27727198472023 @default.
• W2772719847 crossrefType "journal-article" @default.
• W2772719847 hasAuthorship W2772719847A5011003738 @default.
• W2772719847 hasAuthorship W2772719847A5033464248 @default.
• W2772719847 hasAuthorship W2772719847A5034174603 @default.
• W2772719847 hasAuthorship W2772719847A5040236972 @default.
• W2772719847 hasAuthorship W2772719847A5044862107 @default.
• W2772719847 hasAuthorship W2772719847A5055996794 @default.
• W2772719847 hasAuthorship W2772719847A5064049623 @default.
• W2772719847 hasAuthorship W2772719847A5075153200 @default.
• W2772719847 hasAuthorship W2772719847A5086297355 @default.
• W2772719847 hasAuthorship W2772719847A5087536545 @default.
• W2772719847 hasBestOaLocation W27727198471 @default.
• W2772719847 hasConcept C126322002 @default.
• W2772719847 hasConcept C197934379 @default.
• W2772719847 hasConcept C207103383 @default.
• W2772719847 hasConcept C2777793932 @default.
• W2772719847 hasConcept C2778019345 @default.
• W2772719847 hasConcept C2778800853 @default.
• W2772719847 hasConcept C2780868729 @default.
• W2772719847 hasConcept C2989005 @default.
• W2772719847 hasConcept C44249647 @default.
• W2772719847 hasConcept C50382708 @default.
• W2772719847 hasConcept C71924100 @default.
• W2772719847 hasConcept C72563966 @default.
• W2772719847 hasConcept C90924648 @default.
• W2772719847 hasConceptScore W2772719847C126322002 @default.
• W2772719847 hasConceptScore W2772719847C197934379 @default.
• W2772719847 hasConceptScore W2772719847C207103383 @default.
• W2772719847 hasConceptScore W2772719847C2777793932 @default.
• W2772719847 hasConceptScore W2772719847C2778019345 @default.
• W2772719847 hasConceptScore W2772719847C2778800853 @default.
• W2772719847 hasConceptScore W2772719847C2780868729 @default.
• W2772719847 hasConceptScore W2772719847C2989005 @default.
• W2772719847 hasConceptScore W2772719847C44249647 @default.
• W2772719847 hasConceptScore W2772719847C50382708 @default.
• W2772719847 hasConceptScore W2772719847C71924100 @default.
• W2772719847 hasConceptScore W2772719847C72563966 @default.

• next