FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772781837> ?p ?o ?g. }

• W2772781837 endingPage "110489" @default.
• W2772781837 startingPage "110474" @default.
• W2772781837 abstract "AKT (also known as protein kinase B, PKB) plays an important role in cell survival or tumor progression. For these reasons, AKT is an emerging target for cancer therapeutics. Previously our studies showed that mitochondrial E3 ubiquitin protein ligase 1 (MUL1, also known as MULAN/GIDE/MAPL) is suppressed in head and neck cancer (HNC) and acts as negative regulator against AKT. However, the MUL1 regulatory mechanisms remain largely unknown. Here we report that cisplatin (CDDP) induces thyroid cancer cell death through MUL1-AKT axis. Specifically, CDDP-induced MUL1 leads to ubiquitylation of active form of AKT. We also observed that the role of forkhead box O3 (FOXO3) is pivotal in CDDP-induced MUL1 regulation. FOXO3 knock-downed cells show resistance against CDDP-mediated MUL1-AKT axis. CDDP-mediated intracellular ROS increment plays an important role in FOXO3-MUL1-AKT signal pathway. The data provide compelling evidence to support the idea that the regulation of FOXO3-MUL1-AKT axis can be a novel strategy for the treatment of HNC with CDDP." @default.
• W2772781837 created "2017-12-22" @default.
• W2772781837 creator A5043514474 @default.
• W2772781837 creator A5074533771 @default.
• W2772781837 creator A5077539006 @default.
• W2772781837 creator A5081161757 @default.
• W2772781837 creator A5083028758 @default.
• W2772781837 date "2017-11-30" @default.
• W2772781837 modified "2023-10-12" @default.
• W2772781837 title "FOXO3 induces ubiquitylation of AKT through MUL1 regulation" @default.
• W2772781837 cites W1481314844 @default.
• W2772781837 cites W1564408770 @default.
• W2772781837 cites W1935774199 @default.
• W2772781837 cites W1964717481 @default.
• W2772781837 cites W1974873639 @default.
• W2772781837 cites W1975678399 @default.
• W2772781837 cites W1989116783 @default.
• W2772781837 cites W1998155610 @default.
• W2772781837 cites W2001267569 @default.
• W2772781837 cites W2003406618 @default.
• W2772781837 cites W2008364361 @default.
• W2772781837 cites W2012052381 @default.
• W2772781837 cites W2012161830 @default.
• W2772781837 cites W2018992554 @default.
• W2772781837 cites W2019974241 @default.
• W2772781837 cites W2020931266 @default.
• W2772781837 cites W2031260839 @default.
• W2772781837 cites W2033715459 @default.
• W2772781837 cites W2033957457 @default.
• W2772781837 cites W2034201098 @default.
• W2772781837 cites W2035374050 @default.
• W2772781837 cites W2036691369 @default.
• W2772781837 cites W2043610941 @default.
• W2772781837 cites W2046020700 @default.
• W2772781837 cites W2047462858 @default.
• W2772781837 cites W2054024439 @default.
• W2772781837 cites W2054917860 @default.
• W2772781837 cites W2075401349 @default.
• W2772781837 cites W2076174368 @default.
• W2772781837 cites W2082391135 @default.
• W2772781837 cites W2082995383 @default.
• W2772781837 cites W2089622239 @default.
• W2772781837 cites W2091005985 @default.
• W2772781837 cites W2095304369 @default.
• W2772781837 cites W2097733751 @default.
• W2772781837 cites W2099546337 @default.
• W2772781837 cites W2101100014 @default.
• W2772781837 cites W2102154813 @default.
• W2772781837 cites W2104602638 @default.
• W2772781837 cites W2114311689 @default.
• W2772781837 cites W2122314664 @default.
• W2772781837 cites W2124261225 @default.
• W2772781837 cites W2125649123 @default.
• W2772781837 cites W2129242642 @default.
• W2772781837 cites W2134337382 @default.
• W2772781837 cites W2137035181 @default.
• W2772781837 cites W2140228520 @default.
• W2772781837 cites W2146120209 @default.
• W2772781837 cites W2152761185 @default.
• W2772781837 cites W2157633567 @default.
• W2772781837 cites W2168451979 @default.
• W2772781837 cites W2189608867 @default.
• W2772781837 cites W2190517306 @default.
• W2772781837 cites W2217264961 @default.
• W2772781837 cites W2334326846 @default.
• W2772781837 cites W2388163742 @default.
• W2772781837 cites W2606513998 @default.
• W2772781837 cites W4231181804 @default.
• W2772781837 doi "https://doi.org/10.18632/oncotarget.22793" @default.
• W2772781837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5746397" @default.
• W2772781837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29299162" @default.
• W2772781837 hasPublicationYear "2017" @default.
• W2772781837 type Work @default.
• W2772781837 sameAs 2772781837 @default.
• W2772781837 citedByCount "16" @default.
• W2772781837 countsByYear W27727818372018 @default.
• W2772781837 countsByYear W27727818372019 @default.
• W2772781837 countsByYear W27727818372020 @default.
• W2772781837 countsByYear W27727818372021 @default.
• W2772781837 countsByYear W27727818372022 @default.
• W2772781837 countsByYear W27727818372023 @default.
• W2772781837 crossrefType "journal-article" @default.
• W2772781837 hasAuthorship W2772781837A5043514474 @default.
• W2772781837 hasAuthorship W2772781837A5074533771 @default.
• W2772781837 hasAuthorship W2772781837A5077539006 @default.
• W2772781837 hasAuthorship W2772781837A5081161757 @default.
• W2772781837 hasAuthorship W2772781837A5083028758 @default.
• W2772781837 hasBestOaLocation W27727818371 @default.
• W2772781837 hasConcept C168003608 @default.
• W2772781837 hasConcept C502942594 @default.
• W2772781837 hasConcept C62478195 @default.
• W2772781837 hasConcept C75217442 @default.
• W2772781837 hasConcept C86803240 @default.
• W2772781837 hasConcept C95444343 @default.
• W2772781837 hasConceptScore W2772781837C168003608 @default.
• W2772781837 hasConceptScore W2772781837C502942594 @default.
• W2772781837 hasConceptScore W2772781837C62478195 @default.
• W2772781837 hasConceptScore W2772781837C75217442 @default.

• next