FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772798474> ?p ?o ?g. }

• W2772798474 endingPage "114250" @default.
• W2772798474 startingPage "114239" @default.
• W2772798474 abstract "// Lin Sun 1 , Biao Xie 1 , Qiuju Zhang 1 , Yupeng Wang 1 , Xinyu Wang 1 , Bing Gao 1 , Meina Liu 1 and Maoqing Wang 2 1 Department of Epidemiology and Biostatistics, Public Health College, Harbin Medical University, Harbin, P. R. China 2 Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, P. R. China Correspondence to: Meina Liu, email: liumeina369@163.com Maoqing Wang, email: wang_maoqing@126.com Keywords: HSP; HSPN; biomarkers; metabonomics; clinical Received: September 08, 2017     Accepted: October 29, 2017     Published: November 24, 2017 ABSTRACT Background: In children with Henoch-Schonlein purpura (HSP), the severity of Henoch-Schonlein purpura nephritis (HSPN) is considered responsible for the prognosis of HSP. The pathological process from HSP to HSPN is not clear yet and current diagnostic tools have shortcomings in accurate diagnosis of HSPN. This study aims to assess clinical characteristics of HSP and HSPN, to identify metabolic perturbations involved in HSP progress, and to combine metabolic biomarkers and clinical features into a better prediction for HSPN. Methods: A total of 162 children were recruited, including 109 HSP patients and 53 healthy children (HC). The clinical characteristics were compared between HSPN and HSP without nephritis (HSPWN). The serum metabonomics analysis was performed to determine the metabolic differences in HSP and HC. Results: Among 109 HSP children, 57 progressed to HSPN. The increased D-dimer level was significantly associated with renal damage in HSP. The metabonomic profiles revealed alterations between various subgroups of HSP and HC, making it possible to investigate small-molecule metabolites related to the pathological process of HSP. In total, we identified 9 biomarkers for HSP vs. HC, 7 for HSPWN vs. HC, 9 for HSPN vs. HC, and 3 for HSPN vs. HSPWN. Conclusions: (S)-3-hydroxyisobutyric acid, p-Cresol sulfate, and 3-carboxy-4-methyl-5-pentyl-2-furanpropanoic acid were found associated with the progress of HSP to HSPN. Moreover, resulting biomarkers, when combined with D-dimer, allowed improving the HSPN prediction with high sensitivity (94.7%) and specificity (80.8%). Together these findings highlighted the strength of the combination of metabonomics and clinical analysis in the research of HSP." @default.
• W2772798474 created "2017-12-22" @default.
• W2772798474 creator A5013155931 @default.
• W2772798474 creator A5021984184 @default.
• W2772798474 creator A5035247818 @default.
• W2772798474 creator A5037781620 @default.
• W2772798474 creator A5038367972 @default.
• W2772798474 creator A5047701383 @default.
• W2772798474 creator A5056768519 @default.
• W2772798474 creator A5061671086 @default.
• W2772798474 date "2017-11-24" @default.
• W2772798474 modified "2023-10-14" @default.
• W2772798474 title "Biomarkers identification by a combined clinical and metabonomics analysis in Henoch-Schonlein purpura nephritis children" @default.
• W2772798474 cites W120229927 @default.
• W2772798474 cites W1482196516 @default.
• W2772798474 cites W1921797022 @default.
• W2772798474 cites W1963597717 @default.
• W2772798474 cites W1964100139 @default.
• W2772798474 cites W1974072757 @default.
• W2772798474 cites W1975712886 @default.
• W2772798474 cites W1989962362 @default.
• W2772798474 cites W1991992892 @default.
• W2772798474 cites W2061802019 @default.
• W2772798474 cites W2062222093 @default.
• W2772798474 cites W2071514856 @default.
• W2772798474 cites W2078879290 @default.
• W2772798474 cites W2082320092 @default.
• W2772798474 cites W2091161296 @default.
• W2772798474 cites W2095378845 @default.
• W2772798474 cites W2116170087 @default.
• W2772798474 cites W2129559166 @default.
• W2772798474 cites W2161633069 @default.
• W2772798474 cites W2169653055 @default.
• W2772798474 cites W2210346260 @default.
• W2772798474 cites W4247172809 @default.
• W2772798474 cites W58325168 @default.
• W2772798474 doi "https://doi.org/10.18632/oncotarget.23207" @default.
• W2772798474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5768399" @default.
• W2772798474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29371982" @default.
• W2772798474 hasPublicationYear "2017" @default.
• W2772798474 type Work @default.
• W2772798474 sameAs 2772798474 @default.
• W2772798474 citedByCount "10" @default.
• W2772798474 countsByYear W27727984742018 @default.
• W2772798474 countsByYear W27727984742019 @default.
• W2772798474 countsByYear W27727984742020 @default.
• W2772798474 countsByYear W27727984742022 @default.
• W2772798474 countsByYear W27727984742023 @default.
• W2772798474 crossrefType "journal-article" @default.
• W2772798474 hasAuthorship W2772798474A5013155931 @default.
• W2772798474 hasAuthorship W2772798474A5021984184 @default.
• W2772798474 hasAuthorship W2772798474A5035247818 @default.
• W2772798474 hasAuthorship W2772798474A5037781620 @default.
• W2772798474 hasAuthorship W2772798474A5038367972 @default.
• W2772798474 hasAuthorship W2772798474A5047701383 @default.
• W2772798474 hasAuthorship W2772798474A5056768519 @default.
• W2772798474 hasAuthorship W2772798474A5061671086 @default.
• W2772798474 hasBestOaLocation W27727984741 @default.
• W2772798474 hasConcept C107130276 @default.
• W2772798474 hasConcept C126322002 @default.
• W2772798474 hasConcept C18903297 @default.
• W2772798474 hasConcept C203014093 @default.
• W2772798474 hasConcept C207886595 @default.
• W2772798474 hasConcept C2776015282 @default.
• W2772798474 hasConcept C2777058396 @default.
• W2772798474 hasConcept C2777121669 @default.
• W2772798474 hasConcept C2779134260 @default.
• W2772798474 hasConcept C2780013240 @default.
• W2772798474 hasConcept C2781197716 @default.
• W2772798474 hasConcept C55493867 @default.
• W2772798474 hasConcept C71924100 @default.
• W2772798474 hasConcept C86803240 @default.
• W2772798474 hasConceptScore W2772798474C107130276 @default.
• W2772798474 hasConceptScore W2772798474C126322002 @default.
• W2772798474 hasConceptScore W2772798474C18903297 @default.
• W2772798474 hasConceptScore W2772798474C203014093 @default.
• W2772798474 hasConceptScore W2772798474C207886595 @default.
• W2772798474 hasConceptScore W2772798474C2776015282 @default.
• W2772798474 hasConceptScore W2772798474C2777058396 @default.
• W2772798474 hasConceptScore W2772798474C2777121669 @default.
• W2772798474 hasConceptScore W2772798474C2779134260 @default.
• W2772798474 hasConceptScore W2772798474C2780013240 @default.
• W2772798474 hasConceptScore W2772798474C2781197716 @default.
• W2772798474 hasConceptScore W2772798474C55493867 @default.
• W2772798474 hasConceptScore W2772798474C71924100 @default.
• W2772798474 hasConceptScore W2772798474C86803240 @default.
• W2772798474 hasIssue "69" @default.
• W2772798474 hasLocation W27727984741 @default.
• W2772798474 hasLocation W27727984742 @default.
• W2772798474 hasLocation W27727984743 @default.
• W2772798474 hasLocation W27727984744 @default.
• W2772798474 hasOpenAccess W2772798474 @default.
• W2772798474 hasPrimaryLocation W27727984741 @default.
• W2772798474 hasRelatedWork W190387045 @default.
• W2772798474 hasRelatedWork W2140119078 @default.
• W2772798474 hasRelatedWork W2367789390 @default.
• W2772798474 hasRelatedWork W2376281045 @default.
• W2772798474 hasRelatedWork W2377310274 @default.

• next