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- W2772817388 abstract "TPS2605Background: Members of the caspase family of cysteine proteases are key players in both the initiation and execution of apoptosis; the activation of procaspase-3 to caspase-3 is a critical event in the apoptotic cascade. Procaspase-3 levels are elevated in: glioblastoma, breast cancer, colon cancer, lung cancer, lymphoma, neuroblastoma, melanoma, and liver cancer. As a consequence, caspase-3 levels are abnormally low in these tumors, allowing the tumors to avoid apoptosis. PAC-1 is a small molecule that directly activates procaspase-3 and induces apoptosis of cancer cells in culture. PAC-1 showed efficacy across a wide range of cancer cell lines, as well as in animal models of cancer, including brain cancer. This novel compound potently synergizes with chemotherapy agents (e.g.doxorubicin, temozolomide, etoposide, carboplatin). Methods: This is a Phase I dose escalation study with a modified- Fibonacci 3+3 design, consisting of two parts: to determine the maximum tolerated dose (MTD) of PAC-1 in ad..." @default.
- W2772817388 created "2017-12-22" @default.
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- W2772817388 date "2016-05-20" @default.
- W2772817388 modified "2023-10-14" @default.
- W2772817388 title "Phase I study of procaspase activating compound -1 (PAC-1) in the treatment of advanced malignancies." @default.
- W2772817388 doi "https://doi.org/10.1200/jco.2016.34.15_suppl.tps2605" @default.
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