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- W2772872542 abstract "Introduction: Approximately 15% of end-stage renal disease patients are infected with the hepatitis C virus (HCV). Prior studies have demonstrated improved survival for these patients following kidney transplantation compared with those who remain on dialysis. However, risks of kidney transplantation in these patients remain unclear. Methods: We retrospectively reviewed the results of kidney transplants from May 2002 to January 2014 at a single center. During this time 48 patients with chronic HCV received isolated kidney transplants. Of these patients, 43 underwent percutaneous liver biopsy to evaluate their liver disease and were included in our analysis. Survival data were stratified based on the degree of fibrosis seen on biopsy. Results: Median follow-up was 4.8 (0 to 10.7) years. At liver biopsy, 16 (37%) patients had no fibrosis, 13 (30%) had stage 1, and the remaining 14 (33%) had stage 2 or greater. Kaplan-Meier analysis suggests that both patient (p=0.02) and graft survivals (p=0.11) worsen with increasing fibrosis.Table: No Caption available.Conclusions: Kidney transplantation in patients with HCV incurs additional risk as the degree of fibrosis increases. However, the overall 1 and 3-year patient (95% and 93%) and graft survivals (91% and 77%) of this cohort are comparable to those seen for non-HCV patients at this center and nationally. Liver biopsy should be used to stratify patients with ESRD and HCV to better determine their risk profile when considering kidney transplantation." @default.
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- W2772872542 date "2014-07-01" @default.
- W2772872542 modified "2023-09-27" @default.
- W2772872542 title "Outcomes of Renal Transplantation in Recipients With Hepatitis C: A Single Center Study." @default.
- W2772872542 doi "https://doi.org/10.1097/00007890-201407151-02105" @default.
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