FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772912444> ?p ?o ?g. }

• W2772912444 endingPage "1447" @default.
• W2772912444 startingPage "1441" @default.
• W2772912444 abstract "Fibrolamellar carcinomas are characterized by activation of protein kinase A, a kinase composed of catalytic and regulatory subunits. PRKACA encodes a catalytic subunit of protein kinase A, and almost all fibrolamellar carcinomas have a heterozygous 400-kb deletion that leads to the fusion of DNAJB1 and PRKACA. The resulting DNAJB1-PRKACA fusion transcript is believed to activate protein kinase A by dysregulation of the catalytic portion of the protein. In contrast, PRKAR1A encodes one of the regulatory subunits of protein kinase A. We hypothesized that loss of function of this regulatory unit could also lead to protein kinase A activation and thus to fibrolamellar carcinoma. Because PRKAR1A mutations underlie the Carney complex, we searched for liver tumors in individuals with the Carney complex. We identified 3 individuals with fibrolamellar carcinomas and a personal history of the Carney complex. All three tumors displayed the typical morphology of fibrolamellar carcinoma and were positive for arginase, cytokeratin 7, and cluster of differentiation 68. Fluorescence in situ hybridization was negative for PRKACA rearrangements. However, PRKAR1A sequencing identified pathogenic mutations in two of two cases with successful sequencing. In addition, all three cases were negative for PRKAR1A protein expression, consistent with inactivation of this key regulatory unit of protein kinase A. We also identified one additional fibrolamellar carcinoma in an individual without a documented history of the Carney complex who was negative for PRKACA rearrangements but had loss of PRKAR1A protein expression as well as PRKAR1A mutations.Fibrolamellar carcinoma can be part of the Carney complex; in this setting, fibrolamellar carcinomas have inactivating PRKAR1A mutations instead of the DNAJB1-PRKACA fusion gene found in sporadic fibrolamellar carcinomas, providing an alternate means for activation of protein kinase A. (Hepatology 2017)." @default.
• W2772912444 created "2017-12-22" @default.
• W2772912444 creator A5004774815 @default.
• W2772912444 creator A5023044832 @default.
• W2772912444 creator A5036195107 @default.
• W2772912444 creator A5046724542 @default.
• W2772912444 creator A5046806884 @default.
• W2772912444 creator A5057465226 @default.
• W2772912444 creator A5061736352 @default.
• W2772912444 creator A5062226170 @default.
• W2772912444 date "2018-05-11" @default.
• W2772912444 modified "2023-10-11" @default.
• W2772912444 title "Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1‐PRKACA fusion" @default.
• W2772912444 cites W1883944016 @default.
• W2772912444 cites W1894919052 @default.
• W2772912444 cites W1916147164 @default.
• W2772912444 cites W1932450189 @default.
• W2772912444 cites W1972420511 @default.
• W2772912444 cites W1974489853 @default.
• W2772912444 cites W1989363801 @default.
• W2772912444 cites W2008227227 @default.
• W2772912444 cites W2021593686 @default.
• W2772912444 cites W2032118739 @default.
• W2772912444 cites W2038855761 @default.
• W2772912444 cites W2047597784 @default.
• W2772912444 cites W2091735971 @default.
• W2772912444 cites W2124127909 @default.
• W2772912444 cites W2126935974 @default.
• W2772912444 cites W2157073932 @default.
• W2772912444 cites W2192682263 @default.
• W2772912444 cites W2303566232 @default.
• W2772912444 cites W2317019301 @default.
• W2772912444 cites W2319840599 @default.
• W2772912444 cites W2566819134 @default.
• W2772912444 cites W2595139975 @default.
• W2772912444 cites W2753836667 @default.
• W2772912444 cites W4298196662 @default.
• W2772912444 cites W4300886303 @default.
• W2772912444 doi "https://doi.org/10.1002/hep.29719" @default.
• W2772912444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6151295" @default.
• W2772912444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29222914" @default.
• W2772912444 hasPublicationYear "2018" @default.
• W2772912444 type Work @default.
• W2772912444 sameAs 2772912444 @default.
• W2772912444 citedByCount "41" @default.
• W2772912444 countsByYear W27729124442019 @default.
• W2772912444 countsByYear W27729124442020 @default.
• W2772912444 countsByYear W27729124442021 @default.
• W2772912444 countsByYear W27729124442022 @default.
• W2772912444 countsByYear W27729124442023 @default.
• W2772912444 crossrefType "journal-article" @default.
• W2772912444 hasAuthorship W2772912444A5004774815 @default.
• W2772912444 hasAuthorship W2772912444A5023044832 @default.
• W2772912444 hasAuthorship W2772912444A5036195107 @default.
• W2772912444 hasAuthorship W2772912444A5046724542 @default.
• W2772912444 hasAuthorship W2772912444A5046806884 @default.
• W2772912444 hasAuthorship W2772912444A5057465226 @default.
• W2772912444 hasAuthorship W2772912444A5061736352 @default.
• W2772912444 hasAuthorship W2772912444A5062226170 @default.
• W2772912444 hasBestOaLocation W27729124441 @default.
• W2772912444 hasConcept C184235292 @default.
• W2772912444 hasConcept C502942594 @default.
• W2772912444 hasConcept C86803240 @default.
• W2772912444 hasConcept C95444343 @default.
• W2772912444 hasConcept C97029542 @default.
• W2772912444 hasConceptScore W2772912444C184235292 @default.
• W2772912444 hasConceptScore W2772912444C502942594 @default.
• W2772912444 hasConceptScore W2772912444C86803240 @default.
• W2772912444 hasConceptScore W2772912444C95444343 @default.
• W2772912444 hasConceptScore W2772912444C97029542 @default.
• W2772912444 hasIssue "4" @default.
• W2772912444 hasLocation W27729124441 @default.
• W2772912444 hasLocation W27729124442 @default.
• W2772912444 hasLocation W27729124443 @default.
• W2772912444 hasLocation W27729124444 @default.
• W2772912444 hasOpenAccess W2772912444 @default.
• W2772912444 hasPrimaryLocation W27729124441 @default.
• W2772912444 hasRelatedWork W153534931 @default.
• W2772912444 hasRelatedWork W1932635707 @default.
• W2772912444 hasRelatedWork W2082860237 @default.
• W2772912444 hasRelatedWork W2104919212 @default.
• W2772912444 hasRelatedWork W2130076355 @default.
• W2772912444 hasRelatedWork W2155530710 @default.
• W2772912444 hasRelatedWork W2336562918 @default.
• W2772912444 hasRelatedWork W2414298333 @default.
• W2772912444 hasRelatedWork W3188345306 @default.
• W2772912444 hasRelatedWork W4220864307 @default.
• W2772912444 hasVolume "68" @default.
• W2772912444 isParatext "false" @default.
• W2772912444 isRetracted "false" @default.
• W2772912444 magId "2772912444" @default.
• W2772912444 workType "article" @default.