FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772938013> ?p ?o ?g. }

• W2772938013 endingPage "670" @default.
• W2772938013 startingPage "659" @default.
• W2772938013 abstract "Abstract Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer, a tumor characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF). Although CAFs are abundantly present, the effects of RT to CAF and its impact on cancer cells are unknown. We evaluated the damage responses of CAF to RT and investigated changes in colorectal cancer cell growth, transcriptome, metabolome, and kinome in response to paracrine signals emerging from irradiated CAF. RT to CAF induced DNA damage, p53 activation, cell-cycle arrest, and secretion of paracrine mediators, including insulin-like growth factor-1 (IGF1). Subsequently, RT-activated CAFs promoted survival of colorectal cancer cells, as well as a metabolic switch favoring glutamine consumption through IGF1 receptor (IGF1R) activation. RT followed by IGF1R neutralization in orthotopic colorectal cancer models reduced the number of mice with organ metastases. Activation of the downstream IGF1R mediator mTOR was significantly higher in matched (intrapatient) samples and in unmatched (interpatient) samples from rectal cancer patients after neoadjuvant chemoradiotherapy. Taken together, our data support the notion that paracrine IGF1/IGF1R signaling initiated by RT-activated CAF worsens colorectal cancer progression, establishing a preclinical rationale to target this activation loop to further improve clinical responses and patient survival. Significance: These findings reveal that paracrine IGF1/IGF1R signaling promotes colorectal cancer progression, establishing a preclinical rationale to target this activation loop. Cancer Res; 78(3); 659–70. ©2017 AACR." @default.
• W2772938013 created "2017-12-22" @default.
• W2772938013 creator A5017394827 @default.
• W2772938013 creator A5021174597 @default.
• W2772938013 creator A5021283813 @default.
• W2772938013 creator A5022661841 @default.
• W2772938013 creator A5030639316 @default.
• W2772938013 creator A5034687681 @default.
• W2772938013 creator A5042130353 @default.
• W2772938013 creator A5052850973 @default.
• W2772938013 creator A5054431032 @default.
• W2772938013 creator A5056727791 @default.
• W2772938013 creator A5059166590 @default.
• W2772938013 creator A5060808021 @default.
• W2772938013 creator A5061866349 @default.
• W2772938013 creator A5065445325 @default.
• W2772938013 creator A5073205467 @default.
• W2772938013 creator A5073486345 @default.
• W2772938013 creator A5085079548 @default.
• W2772938013 creator A5085695867 @default.
• W2772938013 creator A5086124798 @default.
• W2772938013 date "2018-01-31" @default.
• W2772938013 modified "2023-10-18" @default.
• W2772938013 title "Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation" @default.
• W2772938013 cites W1877248121 @default.
• W2772938013 cites W1912124796 @default.
• W2772938013 cites W1969450298 @default.
• W2772938013 cites W1972624341 @default.
• W2772938013 cites W1974873303 @default.
• W2772938013 cites W1987191213 @default.
• W2772938013 cites W1988138737 @default.
• W2772938013 cites W1996609855 @default.
• W2772938013 cites W2003601710 @default.
• W2772938013 cites W2007445015 @default.
• W2772938013 cites W2023057901 @default.
• W2772938013 cites W2031611276 @default.
• W2772938013 cites W2033751993 @default.
• W2772938013 cites W2035447242 @default.
• W2772938013 cites W2037332721 @default.
• W2772938013 cites W2040879252 @default.
• W2772938013 cites W2079547534 @default.
• W2772938013 cites W2079817874 @default.
• W2772938013 cites W2087677309 @default.
• W2772938013 cites W2092437923 @default.
• W2772938013 cites W2101928585 @default.
• W2772938013 cites W2102810283 @default.
• W2772938013 cites W2102944868 @default.
• W2772938013 cites W2115320363 @default.
• W2772938013 cites W2116910749 @default.
• W2772938013 cites W2122785912 @default.
• W2772938013 cites W2135114065 @default.
• W2772938013 cites W2137496300 @default.
• W2772938013 cites W2144959834 @default.
• W2772938013 cites W2155492044 @default.
• W2772938013 cites W2162278616 @default.
• W2772938013 cites W2170866914 @default.
• W2772938013 cites W2235523093 @default.
• W2772938013 cites W2339072493 @default.
• W2772938013 cites W2503851771 @default.
• W2772938013 cites W2512899508 @default.
• W2772938013 cites W2524848212 @default.
• W2772938013 cites W2530909341 @default.
• W2772938013 cites W2551893887 @default.
• W2772938013 doi "https://doi.org/10.1158/0008-5472.can-17-0524" @default.
• W2772938013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29217764" @default.
• W2772938013 hasPublicationYear "2018" @default.
• W2772938013 type Work @default.
• W2772938013 sameAs 2772938013 @default.
• W2772938013 citedByCount "97" @default.
• W2772938013 countsByYear W27729380132018 @default.
• W2772938013 countsByYear W27729380132019 @default.
• W2772938013 countsByYear W27729380132020 @default.
• W2772938013 countsByYear W27729380132021 @default.
• W2772938013 countsByYear W27729380132022 @default.
• W2772938013 countsByYear W27729380132023 @default.
• W2772938013 crossrefType "journal-article" @default.
• W2772938013 hasAuthorship W2772938013A5017394827 @default.
• W2772938013 hasAuthorship W2772938013A5021174597 @default.
• W2772938013 hasAuthorship W2772938013A5021283813 @default.
• W2772938013 hasAuthorship W2772938013A5022661841 @default.
• W2772938013 hasAuthorship W2772938013A5030639316 @default.
• W2772938013 hasAuthorship W2772938013A5034687681 @default.
• W2772938013 hasAuthorship W2772938013A5042130353 @default.
• W2772938013 hasAuthorship W2772938013A5052850973 @default.
• W2772938013 hasAuthorship W2772938013A5054431032 @default.
• W2772938013 hasAuthorship W2772938013A5056727791 @default.
• W2772938013 hasAuthorship W2772938013A5059166590 @default.
• W2772938013 hasAuthorship W2772938013A5060808021 @default.
• W2772938013 hasAuthorship W2772938013A5061866349 @default.
• W2772938013 hasAuthorship W2772938013A5065445325 @default.
• W2772938013 hasAuthorship W2772938013A5073205467 @default.
• W2772938013 hasAuthorship W2772938013A5073486345 @default.
• W2772938013 hasAuthorship W2772938013A5085079548 @default.
• W2772938013 hasAuthorship W2772938013A5085695867 @default.
• W2772938013 hasAuthorship W2772938013A5086124798 @default.
• W2772938013 hasBestOaLocation W27729380132 @default.
• W2772938013 hasConcept C121608353 @default.
• W2772938013 hasConcept C126322002 @default.

• next