FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2772956520> ?p ?o ?g. }

• W2772956520 endingPage "172" @default.
• W2772956520 startingPage "167" @default.
• W2772956520 abstract "Ketamine, a commonly used anesthetic compound, may cause neurotoxicity in immature or developing brains. In this study, we indented to understand the molecular expression and functional role of Lin-28 Homolog B (lin28b) in regulating ketamine-induced neurotoxicity in neural stem cells (NSCs)-differentiated neurons. NSCs from embryonic rat brains were cultured in vitro, and induced toward neuronal differentiation. NSCs-differentiated neurons were treated with various concentrations of ketamine for 24 h to evaluate the concentration-dependent effect of ketamine on endogenous lin28b mRNA level. QRT-PCR showed that lin28b was downregulated by ketamine in NSCs-differentiated neurons, in concentration-dependent manner. Neurons were then transfected with adenovirus to ectopically upregulate lin28b. We found that ketamine-induced apoptosis and neurite retraction in NSCs-differentiated neurons were significantly reduced by adenovirus-mediated lin28b upregulation. Expression of sex determining region Y box 2 (Sox2) mRNA was examined in ketamine-injured and lin28b-upregulated NSCs-differentiated neurons. It was found Sox2 was downregulated by ketamine, and overexpressed by lin28b upregulation. Finally, Sox2 was downregulated by siRNA in NSCs-differentiated neurons. And we discovered that Lin28b-upregulation-associated neural protection was severely hampered by Sox2 downregulation in ketamine-injured neurons. Thus, Lin28b and Sox2 are important molecular components in ketamine-induced neurotoxicity." @default.
• W2772956520 created "2017-12-22" @default.
• W2772956520 creator A5002405830 @default.
• W2772956520 creator A5050448107 @default.
• W2772956520 creator A5051993838 @default.
• W2772956520 creator A5066738004 @default.
• W2772956520 creator A5072073374 @default.
• W2772956520 creator A5081768837 @default.
• W2772956520 date "2018-02-01" @default.
• W2772956520 modified "2023-10-09" @default.
• W2772956520 title "Lin28b and Sox2 regulate anesthesia-induced neural degeneration in neural stem cell derived neurons" @default.
• W2772956520 cites W1986916431 @default.
• W2772956520 cites W1987497534 @default.
• W2772956520 cites W1991671862 @default.
• W2772956520 cites W1999711595 @default.
• W2772956520 cites W2016971867 @default.
• W2772956520 cites W2017920168 @default.
• W2772956520 cites W2034806022 @default.
• W2772956520 cites W2044459199 @default.
• W2772956520 cites W2051700776 @default.
• W2772956520 cites W2053418969 @default.
• W2772956520 cites W2062376760 @default.
• W2772956520 cites W2085235083 @default.
• W2772956520 cites W2087016406 @default.
• W2772956520 cites W2096356147 @default.
• W2772956520 cites W2135518377 @default.
• W2772956520 cites W2152310279 @default.
• W2772956520 cites W2163513779 @default.
• W2772956520 cites W2443955299 @default.
• W2772956520 cites W613446275 @default.
• W2772956520 doi "https://doi.org/10.1016/j.ejphar.2017.12.031" @default.
• W2772956520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29246852" @default.
• W2772956520 hasPublicationYear "2018" @default.
• W2772956520 type Work @default.
• W2772956520 sameAs 2772956520 @default.
• W2772956520 citedByCount "4" @default.
• W2772956520 countsByYear W27729565202019 @default.
• W2772956520 countsByYear W27729565202022 @default.
• W2772956520 countsByYear W27729565202023 @default.
• W2772956520 crossrefType "journal-article" @default.
• W2772956520 hasAuthorship W2772956520A5002405830 @default.
• W2772956520 hasAuthorship W2772956520A5050448107 @default.
• W2772956520 hasAuthorship W2772956520A5051993838 @default.
• W2772956520 hasAuthorship W2772956520A5066738004 @default.
• W2772956520 hasAuthorship W2772956520A5072073374 @default.
• W2772956520 hasAuthorship W2772956520A5081768837 @default.
• W2772956520 hasConcept C104317684 @default.
• W2772956520 hasConcept C113246987 @default.
• W2772956520 hasConcept C127561419 @default.
• W2772956520 hasConcept C136834591 @default.
• W2772956520 hasConcept C145103041 @default.
• W2772956520 hasConcept C169760540 @default.
• W2772956520 hasConcept C178790620 @default.
• W2772956520 hasConcept C185592680 @default.
• W2772956520 hasConcept C202751555 @default.
• W2772956520 hasConcept C2777933648 @default.
• W2772956520 hasConcept C2779491297 @default.
• W2772956520 hasConcept C28328180 @default.
• W2772956520 hasConcept C29730261 @default.
• W2772956520 hasConcept C4746552 @default.
• W2772956520 hasConcept C55493867 @default.
• W2772956520 hasConcept C86803240 @default.
• W2772956520 hasConcept C95444343 @default.
• W2772956520 hasConceptScore W2772956520C104317684 @default.
• W2772956520 hasConceptScore W2772956520C113246987 @default.
• W2772956520 hasConceptScore W2772956520C127561419 @default.
• W2772956520 hasConceptScore W2772956520C136834591 @default.
• W2772956520 hasConceptScore W2772956520C145103041 @default.
• W2772956520 hasConceptScore W2772956520C169760540 @default.
• W2772956520 hasConceptScore W2772956520C178790620 @default.
• W2772956520 hasConceptScore W2772956520C185592680 @default.
• W2772956520 hasConceptScore W2772956520C202751555 @default.
• W2772956520 hasConceptScore W2772956520C2777933648 @default.
• W2772956520 hasConceptScore W2772956520C2779491297 @default.
• W2772956520 hasConceptScore W2772956520C28328180 @default.
• W2772956520 hasConceptScore W2772956520C29730261 @default.
• W2772956520 hasConceptScore W2772956520C4746552 @default.
• W2772956520 hasConceptScore W2772956520C55493867 @default.
• W2772956520 hasConceptScore W2772956520C86803240 @default.
• W2772956520 hasConceptScore W2772956520C95444343 @default.
• W2772956520 hasLocation W27729565201 @default.
• W2772956520 hasLocation W27729565202 @default.
• W2772956520 hasOpenAccess W2772956520 @default.
• W2772956520 hasPrimaryLocation W27729565201 @default.
• W2772956520 hasRelatedWork W2004228152 @default.
• W2772956520 hasRelatedWork W2019492885 @default.
• W2772956520 hasRelatedWork W2022432765 @default.
• W2772956520 hasRelatedWork W2024025249 @default.
• W2772956520 hasRelatedWork W2045039713 @default.
• W2772956520 hasRelatedWork W2331999951 @default.
• W2772956520 hasRelatedWork W2377956979 @default.
• W2772956520 hasRelatedWork W2409278910 @default.
• W2772956520 hasRelatedWork W2619900882 @default.
• W2772956520 hasRelatedWork W3130449298 @default.
• W2772956520 hasVolume "820" @default.
• W2772956520 isParatext "false" @default.
• W2772956520 isRetracted "false" @default.
• W2772956520 magId "2772956520" @default.

• next