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- W2772981282 abstract "Abstract Objective: In this study, we firstly aimed to determine components of biological variations (BVCs) in levels of glucose and glycated hemoglobin (HbA 1c ) in detail based on guidance from relevant organizations and experts. We also investigated whether reference intervals for both analytes were useful for evaluations, particularly consecutive test results. Methods: The study group consisted of 36 healthy volunteers. Samples were collected from each individual 4 times every 2 weeks for 45 days. All samples were assayed in duplicate within a single run. Finally, we estimated BVCs and the analytical performance specifications of both analytes. Results: Our results were fairly compatible with current biological variations (BVs) in both analytes reported in a database. It was calculated as within biological variation (CV I )=4.2% and between-subject variation (CV G )=5.3% for glucose while calculating as CV I =1.7% and CV G =4.5% for HbA 1c . According to these results, the index of individuality (II) of glucose was higher than 0.6 while HbA 1c ’s II was lower than this value. Conclusion: We thought that guidelines from relevant international organizations should be followed to standardize the study design and to appropriately calculate BVCs for any analyte in BV studies. Finally, reference change value should be used to evaluate meaningful differences in HbA 1c levels instead of reference interval." @default.
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- W2772981282 date "2017-12-08" @default.
- W2772981282 modified "2023-10-18" @default.
- W2772981282 title "Evaluation of biological variations in glucose and glycated hemoglobin levels in healthy individuals" @default.
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- W2772981282 doi "https://doi.org/10.1515/tjb-2017-0165" @default.
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