FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2773190304> ?p ?o ?g. }

• W2773190304 endingPage "317" @default.
• W2773190304 startingPage "310" @default.
• W2773190304 abstract "Multiple sclerosis (MS) is the most common demyelinating disease. Despite the historical use of interferon-beta (IFN-β) for the treatment of patients with MS, concerns exist regarding the side effects of IFN-β. In this study, we designed a series of novel IFN-β fusion proteins containing galectin-9 (gal-9), which exerts immunosuppressive effects through the binding to its receptor on activated Th1 cells. We hypothesized that these fusion proteins would improve the therapeutic effects and reduce the side effects of IFN-β. The IFN-β-gal-9 fusion proteins showed less IFN-β biological activity on non-T cells than IFN-β alone. In vitro experiments using re-stimulated T cells isolated from mice with experimental autoimmune encephalomyelitis (EAE) showed that the IFN-β-gal-9 fusion proteins suppressed activated T cells more effectively than IFN-β. Moreover, in our in vivo experiments, the gene transfer of IFN-β-gal-9 fusion protein-expressing plasmid DNA into EAE mice showed beneficial therapeutic effects without cytopenia, a known side effect of IFN-β. In contrast, the gene transfer of IFN-β-expressing plasmid DNA induced a rapid decrease in the white blood cell count, despite its therapeutic effect. These results indicate that gene therapy using IFN-β-gal-9 fusion proteins is expected to be safe and effective for the treatment of MS." @default.
• W2773190304 created "2017-12-22" @default.
• W2773190304 creator A5028043688 @default.
• W2773190304 creator A5032948413 @default.
• W2773190304 creator A5035791716 @default.
• W2773190304 creator A5059584473 @default.
• W2773190304 creator A5071041099 @default.
• W2773190304 date "2018-01-01" @default.
• W2773190304 modified "2023-09-24" @default.
• W2773190304 title "Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins" @default.
• W2773190304 cites W1660059067 @default.
• W2773190304 cites W1824097817 @default.
• W2773190304 cites W1977067868 @default.
• W2773190304 cites W1986173197 @default.
• W2773190304 cites W2011021908 @default.
• W2773190304 cites W2013177587 @default.
• W2773190304 cites W2039843867 @default.
• W2773190304 cites W2043258301 @default.
• W2773190304 cites W2049886038 @default.
• W2773190304 cites W2070631889 @default.
• W2773190304 cites W2071270620 @default.
• W2773190304 cites W2076724835 @default.
• W2773190304 cites W2094812481 @default.
• W2773190304 cites W2131032184 @default.
• W2773190304 cites W2153958936 @default.
• W2773190304 cites W2282856023 @default.
• W2773190304 cites W2320147764 @default.
• W2773190304 cites W2527258465 @default.
• W2773190304 cites W2591988319 @default.
• W2773190304 cites W2732356469 @default.
• W2773190304 doi "https://doi.org/10.1016/j.ijpharm.2017.12.010" @default.
• W2773190304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29217470" @default.
• W2773190304 hasPublicationYear "2018" @default.
• W2773190304 type Work @default.
• W2773190304 sameAs 2773190304 @default.
• W2773190304 citedByCount "10" @default.
• W2773190304 countsByYear W27731903042019 @default.
• W2773190304 countsByYear W27731903042020 @default.
• W2773190304 countsByYear W27731903042021 @default.
• W2773190304 countsByYear W27731903042022 @default.
• W2773190304 countsByYear W27731903042023 @default.
• W2773190304 crossrefType "journal-article" @default.
• W2773190304 hasAuthorship W2773190304A5028043688 @default.
• W2773190304 hasAuthorship W2773190304A5032948413 @default.
• W2773190304 hasAuthorship W2773190304A5035791716 @default.
• W2773190304 hasAuthorship W2773190304A5059584473 @default.
• W2773190304 hasAuthorship W2773190304A5071041099 @default.
• W2773190304 hasConcept C104317684 @default.
• W2773190304 hasConcept C111599444 @default.
• W2773190304 hasConcept C111829193 @default.
• W2773190304 hasConcept C123894998 @default.
• W2773190304 hasConcept C153911025 @default.
• W2773190304 hasConcept C202751555 @default.
• W2773190304 hasConcept C203014093 @default.
• W2773190304 hasConcept C207001950 @default.
• W2773190304 hasConcept C2776178377 @default.
• W2773190304 hasConcept C2778486448 @default.
• W2773190304 hasConcept C2780640218 @default.
• W2773190304 hasConcept C40767141 @default.
• W2773190304 hasConcept C502942594 @default.
• W2773190304 hasConcept C54355233 @default.
• W2773190304 hasConcept C55493867 @default.
• W2773190304 hasConcept C86803240 @default.
• W2773190304 hasConceptScore W2773190304C104317684 @default.
• W2773190304 hasConceptScore W2773190304C111599444 @default.
• W2773190304 hasConceptScore W2773190304C111829193 @default.
• W2773190304 hasConceptScore W2773190304C123894998 @default.
• W2773190304 hasConceptScore W2773190304C153911025 @default.
• W2773190304 hasConceptScore W2773190304C202751555 @default.
• W2773190304 hasConceptScore W2773190304C203014093 @default.
• W2773190304 hasConceptScore W2773190304C207001950 @default.
• W2773190304 hasConceptScore W2773190304C2776178377 @default.
• W2773190304 hasConceptScore W2773190304C2778486448 @default.
• W2773190304 hasConceptScore W2773190304C2780640218 @default.
• W2773190304 hasConceptScore W2773190304C40767141 @default.
• W2773190304 hasConceptScore W2773190304C502942594 @default.
• W2773190304 hasConceptScore W2773190304C54355233 @default.
• W2773190304 hasConceptScore W2773190304C55493867 @default.
• W2773190304 hasConceptScore W2773190304C86803240 @default.
• W2773190304 hasFunder F4320311405 @default.
• W2773190304 hasFunder F4320334764 @default.
• W2773190304 hasIssue "1" @default.
• W2773190304 hasLocation W27731903041 @default.
• W2773190304 hasLocation W27731903042 @default.
• W2773190304 hasOpenAccess W2773190304 @default.
• W2773190304 hasPrimaryLocation W27731903041 @default.
• W2773190304 hasRelatedWork W144403824 @default.
• W2773190304 hasRelatedWork W1990410752 @default.
• W2773190304 hasRelatedWork W1999407296 @default.
• W2773190304 hasRelatedWork W2054843986 @default.
• W2773190304 hasRelatedWork W2182774377 @default.
• W2773190304 hasRelatedWork W2410817131 @default.
• W2773190304 hasRelatedWork W2411508074 @default.
• W2773190304 hasRelatedWork W2973460871 @default.
• W2773190304 hasRelatedWork W4237802932 @default.
• W2773190304 hasRelatedWork W120488427 @default.
• W2773190304 hasVolume "536" @default.
• W2773190304 isParatext "false" @default.

• next