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- W2773193505 abstract "The evolution of the pituitary hormone, ACTH, the melanocortin receptors, a family of G protein-coupled receptors, and the melanocortin receptor accessory proteins, MRAP1 and MRAP2, are intertwined, and parallel the evolution of the chordates. While all melanocortin-related peptides (i.e., ACTH, αMSH, βMSH, γMSH, δMSH) have the canonical HFRW amino acid motif required for activation of melanocortin receptors (i.e., MC1R, MC2R, MC3R, MC4R, MC5R), during the radiation of the gnathostomes (jawed vertebrates) the ligand selectivity of melanocortin-2 receptor orthologs has diverged between cartilaginous fishes and bony vertebrates in a manner that has implications for the Hypothalamus/Pituitary/Adrenal-Interrenal axis." @default.
- W2773193505 created "2017-12-22" @default.
- W2773193505 creator A5067636916 @default.
- W2773193505 date "2017-01-01" @default.
- W2773193505 modified "2023-09-25" @default.
- W2773193505 title "ACTH, Melanocortin Receptors, and MRAP Accessory Proteins" @default.
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- W2773193505 doi "https://doi.org/10.1016/b978-0-12-801238-3.95733-7" @default.
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