Matches in SemOpenAlex for { <https://semopenalex.org/work/W2773214667> ?p ?o ?g. }
- W2773214667 endingPage "52" @default.
- W2773214667 startingPage "52" @default.
- W2773214667 abstract "A set 
 
 
 X
 
 
 of 20 trinucleotides has been found to have the highest average occurrence in the reading frame, compared to the two shifted frames, of genes of bacteria, archaea, eukaryotes, plasmids and viruses. This set 
 
 
 X
 
 
 has an interesting mathematical property, since 
 
 
 X
 
 
 is a maximal 
 
 
 
 
 C
 3
 
 
 
 
 self-complementary trinucleotide circular code. Furthermore, any motif obtained from this circular code 
 
 
 X
 
 
 has the capacity to retrieve, maintain and synchronize the original (reading) frame. Since 1996, the theory of circular codes in genes has mainly been developed by analysing the properties of the 20 trinucleotides of 
 
 
 X
 
 
 , using combinatorics and statistical approaches. For the first time, we test this theory by analysing the 
 
 
 X
 
 
 motifs, i.e., motifs from the circular code 
 
 
 X
 
 
 , in the complete genome of the yeast Saccharomyces cerevisiae. Several properties of 
 
 
 X
 
 
 motifs are identified by basic statistics (at the frequency level), and evaluated by comparison to 
 
 
 R
 
 
 motifs, i.e., random motifs generated from 30 different random codes 
 
 
 R
 
 
 . We first show that the frequency of 
 
 
 X
 
 
 motifs is significantly greater than that of 
 
 
 R
 
 
 motifs in the genome of S. cerevisiae. We then verify that no significant difference is observed between the frequencies of 
 
 
 X
 
 
 and 
 
 
 R
 
 
 motifs in the non-coding regions of S. cerevisiae, but that the occurrence number of 
 
 
 X
 
 
 motifs is significantly higher than 
 
 
 R
 
 
 motifs in the genes (protein-coding regions). This property is true for all cardinalities of 
 
 
 X
 
 
 motifs (from 4 to 20) and for all 16 chromosomes. We further investigate the distribution of 
 
 
 X
 
 
 motifs in the three frames of S. cerevisiae genes and show that they occur more frequently in the reading frame, regardless of their cardinality or their length. Finally, the ratio of 
 
 
 X
 
 
 genes, i.e., genes with at least one 
 
 
 X
 
 
 motif, to non-
 
 
 X
 
 
 genes, in the set of verified genes is significantly different to that observed in the set of putative or dubious genes with no experimental evidence. These results, taken together, represent the first evidence for a significant enrichment of 
 
 
 X
 
 
 motifs in the genes of an extant organism. They raise two hypotheses: the 
 
 
 X
 
 
 motifs may be evolutionary relics of the primitive codes used for translation, or they may continue to play a functional role in the complex processes of genome decoding and protein synthesis." @default.
- W2773214667 created "2017-12-22" @default.
- W2773214667 creator A5025255544 @default.
- W2773214667 creator A5036832777 @default.
- W2773214667 creator A5038602899 @default.
- W2773214667 creator A5039921905 @default.
- W2773214667 creator A5042433336 @default.
- W2773214667 date "2017-12-03" @default.
- W2773214667 modified "2023-09-30" @default.
- W2773214667 title "Enrichment of Circular Code Motifs in the Genes of the Yeast Saccharomyces cerevisiae" @default.
- W2773214667 cites W1988847495 @default.
- W2773214667 cites W1989029725 @default.
- W2773214667 cites W1992506148 @default.
- W2773214667 cites W1995337374 @default.
- W2773214667 cites W2005324344 @default.
- W2773214667 cites W2014091387 @default.
- W2773214667 cites W2030555609 @default.
- W2773214667 cites W2049504096 @default.
- W2773214667 cites W2059271683 @default.
- W2773214667 cites W2074879476 @default.
- W2773214667 cites W2075130293 @default.
- W2773214667 cites W2076108311 @default.
- W2773214667 cites W2081933515 @default.
- W2773214667 cites W2088549477 @default.
- W2773214667 cites W2101312774 @default.
- W2773214667 cites W2128042413 @default.
- W2773214667 cites W2153283265 @default.
- W2773214667 cites W2155862593 @default.
- W2773214667 cites W2164851008 @default.
- W2773214667 cites W2290147816 @default.
- W2773214667 cites W2410790038 @default.
- W2773214667 cites W2591285222 @default.
- W2773214667 cites W2592229432 @default.
- W2773214667 cites W2606343920 @default.
- W2773214667 cites W2613032334 @default.
- W2773214667 cites W2615184070 @default.
- W2773214667 cites W2707607619 @default.
- W2773214667 cites W2762617464 @default.
- W2773214667 cites W3000068290 @default.
- W2773214667 cites W3125467382 @default.
- W2773214667 cites W4240695170 @default.
- W2773214667 cites W4246040709 @default.
- W2773214667 doi "https://doi.org/10.3390/life7040052" @default.
- W2773214667 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5745565" @default.
- W2773214667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29207500" @default.
- W2773214667 hasPublicationYear "2017" @default.
- W2773214667 type Work @default.
- W2773214667 sameAs 2773214667 @default.
- W2773214667 citedByCount "6" @default.
- W2773214667 countsByYear W27732146672018 @default.
- W2773214667 countsByYear W27732146672019 @default.
- W2773214667 countsByYear W27732146672020 @default.
- W2773214667 crossrefType "journal-article" @default.
- W2773214667 hasAuthorship W2773214667A5025255544 @default.
- W2773214667 hasAuthorship W2773214667A5036832777 @default.
- W2773214667 hasAuthorship W2773214667A5038602899 @default.
- W2773214667 hasAuthorship W2773214667A5039921905 @default.
- W2773214667 hasAuthorship W2773214667A5042433336 @default.
- W2773214667 hasBestOaLocation W27732146671 @default.
- W2773214667 hasConcept C104317684 @default.
- W2773214667 hasConcept C121332964 @default.
- W2773214667 hasConcept C141231307 @default.
- W2773214667 hasConcept C167625842 @default.
- W2773214667 hasConcept C22744801 @default.
- W2773214667 hasConcept C24890656 @default.
- W2773214667 hasConcept C2777576037 @default.
- W2773214667 hasConcept C32276052 @default.
- W2773214667 hasConcept C47289529 @default.
- W2773214667 hasConcept C54355233 @default.
- W2773214667 hasConcept C550995028 @default.
- W2773214667 hasConcept C70721500 @default.
- W2773214667 hasConcept C86803240 @default.
- W2773214667 hasConceptScore W2773214667C104317684 @default.
- W2773214667 hasConceptScore W2773214667C121332964 @default.
- W2773214667 hasConceptScore W2773214667C141231307 @default.
- W2773214667 hasConceptScore W2773214667C167625842 @default.
- W2773214667 hasConceptScore W2773214667C22744801 @default.
- W2773214667 hasConceptScore W2773214667C24890656 @default.
- W2773214667 hasConceptScore W2773214667C2777576037 @default.
- W2773214667 hasConceptScore W2773214667C32276052 @default.
- W2773214667 hasConceptScore W2773214667C47289529 @default.
- W2773214667 hasConceptScore W2773214667C54355233 @default.
- W2773214667 hasConceptScore W2773214667C550995028 @default.
- W2773214667 hasConceptScore W2773214667C70721500 @default.
- W2773214667 hasConceptScore W2773214667C86803240 @default.
- W2773214667 hasIssue "4" @default.
- W2773214667 hasLocation W27732146671 @default.
- W2773214667 hasLocation W27732146672 @default.
- W2773214667 hasLocation W27732146673 @default.
- W2773214667 hasLocation W27732146674 @default.
- W2773214667 hasOpenAccess W2773214667 @default.
- W2773214667 hasPrimaryLocation W27732146671 @default.
- W2773214667 hasRelatedWork W1571771606 @default.
- W2773214667 hasRelatedWork W1804803703 @default.
- W2773214667 hasRelatedWork W1973500773 @default.
- W2773214667 hasRelatedWork W2097499709 @default.
- W2773214667 hasRelatedWork W2159284935 @default.
- W2773214667 hasRelatedWork W2414030161 @default.