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- W2773266141 abstract "MiR-185 was previously shown downregulated in IPF as in LC. Mir185 targets DNA methyltransferase 1 (DNMT1) and regulate cellular proliferation through an AKT-dependent pathway. MiR-29a, also downregulated both in IPF and LC, is involved in major pathogenetic pathways. The aim of our study is to investigate the levels of miR185 and mir29a in LC BAL, as we have previously identified them downregulated in IPF. BALF cells from 56 IPF and 32 LC patients were included. MiR-185, miR29a and corresponding mRNA targets (DNMT1, DNMT3b, AKT1, AKT2, COX2, COL1A1) were analysed by RT-PCR. Western blotting was also conducted. Expression levels were evaluated according to disease, age, smoking and lung function status. A similar expression of miR-185 and miR-29a in IPF and LC was detected. However, we observed decrease in the expression of DNMT1 in LC relative to IPF samples (p=0.01). The expression of miR-185 and miR29a were negatively correlated with both DNMT1 and DNMT3b in IPF, however, in LC no correlation was detected. AKT2 was found positively correlated with DNMT1 and DNMT3b, both in IPF and LC. It was negatively correlated with miR185 in IPF while positively correlated with miR-29a in the LC group. These results suggest possible overlap between pathogenetic mechanisms in IPF and LC BAL cells with respect to microRNA levels tested. However it appears that DNMT1 is further decreased in the BAL cells of LC patients." @default.
- W2773266141 created "2017-12-22" @default.
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- W2773266141 date "2017-09-01" @default.
- W2773266141 modified "2023-09-23" @default.
- W2773266141 title "The expression of miR185, miR29a and their targets in IPF and lung cancer (LC). A BALF study" @default.
- W2773266141 doi "https://doi.org/10.1183/1393003.congress-2017.oa480" @default.
- W2773266141 hasPublicationYear "2017" @default.
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