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• W2773269035 abstract "The efficient preparation of protein bioconjugates represents a route to novel materials, diagnostics, and therapeutics. We previously reported a novel bioorthogonal Glaser-Hay reaction for the preparation of covalent linkages between proteins and a reaction partner; however, deleterious protein degradation was observed under extended reaction conditions. Herein, we describe the systematic optimization of the reaction to increase coupling efficiency and decrease protein degradation. Two optimized conditions were identified varying either the pH of the reaction or the bidentate ligand employed, allowing for more rapid conjugations and/or less protein oxidation." @default.
• W2773269035 created "2017-12-22" @default.
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• W2773269035 date "2018-02-01" @default.
• W2773269035 modified "2023-10-14" @default.
• W2773269035 title "Development of optimized conditions for Glaser-Hay bioconjugations" @default.
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• W2773269035 doi "https://doi.org/10.1016/j.bioorg.2017.11.020" @default.
• W2773269035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5818283" @default.
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• W2773269035 hasPublicationYear "2018" @default.
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