FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2773279134> ?p ?o ?g. }

• W2773279134 abstract "Abstract The Rab‐family GTPases mainly regulate intracellular vesicle transport, and play important roles in the innate immune response in invertebrates. However, the function and signal transduction of Rab proteins in immune reactions remain unclear in silkworms. In this study, we analyzed a Rab‐related protein of silkworm Bombyx mori (BmRABRP) by raising antibodies against its bacterially expressed recombinant form. Tissue distribution analysis showed that BmRABRP mRNA and protein were high expressed in the Malpighian tubule and fat body, respectively. However, among the different stages, only the fourth instar larvae and pupae showed significant BmRABRP levels. After challenge with four pathogenic microorganisms ( Escherichia coli , BmNPV , Beauveria bassiana , Micrococcus luteus ), the expression of BmRABRP mRNA in the fat body was significantly upregulated. In contrast, the BmRABRP protein was significantly upregulated after infection with BmNPV , while it was downregulated by E. coli , B. bassiana , and M. luteus . A specific dsRNA was used to explore the immune function and relationship between BmRABRP and the JAK‐STAT signaling pathway. After BmRABRP gene interference, significant reduction in the number of nodules and increased mortality suggested that BmRABRP plays an important role in silkworm's response to bacterial challenge. In addition, four key genes ( BmHOP , BmSTAT , BmSOCS2 , and BmSOCS6 ) of the JAK‐STAT signaling pathway showed significantly altered expressions after BmRABRP silencing. BmHOP and BmSOCS6 expressions were significantly decreased, while BmSTAT and BmSOCS2 were significantly upregulated. Our results suggested that BmRABRP is involved in the innate immune response against pathogenic microorganisms through the JAK‐STAT signaling pathway in silkworm." @default.
• W2773279134 created "2017-12-22" @default.
• W2773279134 creator A5004076590 @default.
• W2773279134 creator A5004905770 @default.
• W2773279134 creator A5052899332 @default.
• W2773279134 creator A5063253432 @default.
• W2773279134 creator A5070213921 @default.
• W2773279134 creator A5073216396 @default.
• W2773279134 creator A5084892103 @default.
• W2773279134 creator A5089128689 @default.
• W2773279134 date "2017-11-30" @default.
• W2773279134 modified "2023-10-01" @default.
• W2773279134 title "Immune function of a Rab-related protein by modulating the JAK-STAT signaling pathway in the silkworm,<i>Bombyx mori</i>" @default.
• W2773279134 cites W1594427045 @default.
• W2773279134 cites W1595083713 @default.
• W2773279134 cites W1679992491 @default.
• W2773279134 cites W1967190456 @default.
• W2773279134 cites W1975510716 @default.
• W2773279134 cites W1988832749 @default.
• W2773279134 cites W1991019089 @default.
• W2773279134 cites W1994668150 @default.
• W2773279134 cites W1999570717 @default.
• W2773279134 cites W2000975287 @default.
• W2773279134 cites W2002117801 @default.
• W2773279134 cites W2002545338 @default.
• W2773279134 cites W2002568105 @default.
• W2773279134 cites W2003573674 @default.
• W2773279134 cites W2007199665 @default.
• W2773279134 cites W2018211049 @default.
• W2773279134 cites W2018985617 @default.
• W2773279134 cites W2034446338 @default.
• W2773279134 cites W2036006438 @default.
• W2773279134 cites W2040649045 @default.
• W2773279134 cites W2040779714 @default.
• W2773279134 cites W2047561028 @default.
• W2773279134 cites W2049397085 @default.
• W2773279134 cites W2062025882 @default.
• W2773279134 cites W2070223892 @default.
• W2773279134 cites W2073397397 @default.
• W2773279134 cites W2074574014 @default.
• W2773279134 cites W2077904579 @default.
• W2773279134 cites W2083259496 @default.
• W2773279134 cites W2094585531 @default.
• W2773279134 cites W2095516121 @default.
• W2773279134 cites W2098664089 @default.
• W2773279134 cites W2099991247 @default.
• W2773279134 cites W2107277218 @default.
• W2773279134 cites W2109590726 @default.
• W2773279134 cites W2120829444 @default.
• W2773279134 cites W2132632499 @default.
• W2773279134 cites W2139934991 @default.
• W2773279134 cites W2140980122 @default.
• W2773279134 cites W2141121523 @default.
• W2773279134 cites W2143062219 @default.
• W2773279134 cites W2147257825 @default.
• W2773279134 cites W2147666668 @default.
• W2773279134 cites W2156358326 @default.
• W2773279134 cites W2165513989 @default.
• W2773279134 cites W2289953697 @default.
• W2773279134 cites W2297511125 @default.
• W2773279134 cites W2527589229 @default.
• W2773279134 cites W2572549998 @default.
• W2773279134 cites W2602990422 @default.
• W2773279134 cites W2734727679 @default.
• W2773279134 cites W4256157163 @default.
• W2773279134 doi "https://doi.org/10.1002/arch.21434" @default.
• W2773279134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29193252" @default.
• W2773279134 hasPublicationYear "2017" @default.
• W2773279134 type Work @default.
• W2773279134 sameAs 2773279134 @default.
• W2773279134 citedByCount "13" @default.
• W2773279134 countsByYear W27732791342019 @default.
• W2773279134 countsByYear W27732791342020 @default.
• W2773279134 countsByYear W27732791342021 @default.
• W2773279134 countsByYear W27732791342022 @default.
• W2773279134 countsByYear W27732791342023 @default.
• W2773279134 crossrefType "journal-article" @default.
• W2773279134 hasAuthorship W2773279134A5004076590 @default.
• W2773279134 hasAuthorship W2773279134A5004905770 @default.
• W2773279134 hasAuthorship W2773279134A5052899332 @default.
• W2773279134 hasAuthorship W2773279134A5063253432 @default.
• W2773279134 hasAuthorship W2773279134A5070213921 @default.
• W2773279134 hasAuthorship W2773279134A5073216396 @default.
• W2773279134 hasAuthorship W2773279134A5084892103 @default.
• W2773279134 hasAuthorship W2773279134A5089128689 @default.
• W2773279134 hasConcept C104317684 @default.
• W2773279134 hasConcept C136449434 @default.
• W2773279134 hasConcept C156728348 @default.
• W2773279134 hasConcept C157333092 @default.
• W2773279134 hasConcept C166703698 @default.
• W2773279134 hasConcept C203014093 @default.
• W2773279134 hasConcept C207332259 @default.
• W2773279134 hasConcept C2778332815 @default.
• W2773279134 hasConcept C2778487026 @default.
• W2773279134 hasConcept C42362537 @default.
• W2773279134 hasConcept C55493867 @default.
• W2773279134 hasConcept C62478195 @default.
• W2773279134 hasConcept C67705224 @default.
• W2773279134 hasConcept C86803240 @default.
• W2773279134 hasConcept C8891405 @default.

• next