FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2773279968> ?p ?o ?g. }

• W2773279968 endingPage "308" @default.
• W2773279968 startingPage "300" @default.
• W2773279968 abstract "Objective Rheumatoid arthritis (RA) accompanies infiltration and activation of monocytes in inflamed joints. We investigated dominant alterations of RA monocytes in bone marrow (BM), blood and inflamed joints. Methods CD14 + cells from BM and peripheral blood (PB) of patients with RA and osteoarthritis (OA) were profiled with GeneChip microarrays. Detailed functional analysis was performed with reference transcriptomes of BM precursors, monocyte blood subsets, monocyte activation and mobilisation. Cytometric profiling determined monocyte subsets of CD14 ++ CD16 − , CD14 ++ CD16 + and CD14 + CD16 + cells in BM, PB and synovial fluid (SF) and ELISAs quantified the release of activation markers into SF and serum. Results Investigation of genes differentially expressed between RA and OA monocytes with reference transcriptomes revealed gene patterns of early myeloid precursors in RA-BM and late myeloid precursors along with reduced terminal differentiation to CD14 + CD16 + monocytes in RA-PB. Patterns associated with tumor necrosis factor/lipopolysaccharide (TNF/LPS) stimulation were weak and more pronounced in RA-PB than RA-BM. Cytometric phenotyping of cells in BM, blood and SF disclosed differences related to monocyte subsets and confirmed the reduced frequency of terminally differentiated CD14 + CD16 + monocytes in RA-PB. Monocyte activation in SF was characterised by the predominance of CD14 ++ CD16 ++ CD163 + HLA-DR + cells and elevated concentrations of sCD14, sCD163 and S100P. Conclusion Patterns of less mature and less differentiated RA-BM and RA-PB monocytes suggest increased turnover with accelerated monocytopoiesis, BM egress and migration into inflamed joints. Predominant activation in the joint indicates the action of local and primary stimuli, which may also promote adaptive immune triggering through monocytes, potentially leading to new diagnostic and therapeutic strategies." @default.
• W2773279968 created "2017-12-22" @default.
• W2773279968 creator A5000021492 @default.
• W2773279968 creator A5001271955 @default.
• W2773279968 creator A5002527374 @default.
• W2773279968 creator A5006663741 @default.
• W2773279968 creator A5019904842 @default.
• W2773279968 creator A5022474029 @default.
• W2773279968 creator A5029099340 @default.
• W2773279968 creator A5035903343 @default.
• W2773279968 creator A5036865032 @default.
• W2773279968 creator A5044174191 @default.
• W2773279968 creator A5044694911 @default.
• W2773279968 creator A5046382872 @default.
• W2773279968 creator A5055757758 @default.
• W2773279968 creator A5068423984 @default.
• W2773279968 creator A5071091899 @default.
• W2773279968 creator A5074583063 @default.
• W2773279968 creator A5079868934 @default.
• W2773279968 creator A5085554938 @default.
• W2773279968 creator A5089561663 @default.
• W2773279968 creator A5090288111 @default.
• W2773279968 date "2017-11-30" @default.
• W2773279968 modified "2023-10-13" @default.
• W2773279968 title "Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint" @default.
• W2773279968 cites W169181863 @default.
• W2773279968 cites W1712930509 @default.
• W2773279968 cites W1905345815 @default.
• W2773279968 cites W1930766611 @default.
• W2773279968 cites W1950157112 @default.
• W2773279968 cites W1955443929 @default.
• W2773279968 cites W1966356232 @default.
• W2773279968 cites W1975315856 @default.
• W2773279968 cites W1978016270 @default.
• W2773279968 cites W1981300029 @default.
• W2773279968 cites W1984364643 @default.
• W2773279968 cites W1984378291 @default.
• W2773279968 cites W1992101711 @default.
• W2773279968 cites W1996254162 @default.
• W2773279968 cites W2003328421 @default.
• W2773279968 cites W2004070471 @default.
• W2773279968 cites W2006194219 @default.
• W2773279968 cites W2011480812 @default.
• W2773279968 cites W2015141049 @default.
• W2773279968 cites W2016812500 @default.
• W2773279968 cites W2031154201 @default.
• W2773279968 cites W2044247010 @default.
• W2773279968 cites W2053787970 @default.
• W2773279968 cites W2055620105 @default.
• W2773279968 cites W2056162124 @default.
• W2773279968 cites W2063680739 @default.
• W2773279968 cites W2066170238 @default.
• W2773279968 cites W2066638346 @default.
• W2773279968 cites W2082492330 @default.
• W2773279968 cites W2093498736 @default.
• W2773279968 cites W2130509386 @default.
• W2773279968 cites W2133037602 @default.
• W2773279968 cites W2135703618 @default.
• W2773279968 cites W2149840720 @default.
• W2773279968 cites W2152188450 @default.
• W2773279968 cites W2152870596 @default.
• W2773279968 cites W2153932008 @default.
• W2773279968 cites W2158291913 @default.
• W2773279968 cites W2161384788 @default.
• W2773279968 cites W2167446675 @default.
• W2773279968 cites W2224536942 @default.
• W2773279968 cites W2413213144 @default.
• W2773279968 cites W2419520222 @default.
• W2773279968 cites W2511173196 @default.
• W2773279968 cites W2560381583 @default.
• W2773279968 cites W584440894 @default.
• W2773279968 doi "https://doi.org/10.1136/annrheumdis-2017-211649" @default.
• W2773279968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5867420" @default.
• W2773279968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29191820" @default.
• W2773279968 hasPublicationYear "2017" @default.
• W2773279968 type Work @default.
• W2773279968 sameAs 2773279968 @default.
• W2773279968 citedByCount "52" @default.
• W2773279968 countsByYear W27732799682018 @default.
• W2773279968 countsByYear W27732799682019 @default.
• W2773279968 countsByYear W27732799682020 @default.
• W2773279968 countsByYear W27732799682021 @default.
• W2773279968 countsByYear W27732799682022 @default.
• W2773279968 countsByYear W27732799682023 @default.
• W2773279968 crossrefType "journal-article" @default.
• W2773279968 hasAuthorship W2773279968A5000021492 @default.
• W2773279968 hasAuthorship W2773279968A5001271955 @default.
• W2773279968 hasAuthorship W2773279968A5002527374 @default.
• W2773279968 hasAuthorship W2773279968A5006663741 @default.
• W2773279968 hasAuthorship W2773279968A5019904842 @default.
• W2773279968 hasAuthorship W2773279968A5022474029 @default.
• W2773279968 hasAuthorship W2773279968A5029099340 @default.
• W2773279968 hasAuthorship W2773279968A5035903343 @default.
• W2773279968 hasAuthorship W2773279968A5036865032 @default.
• W2773279968 hasAuthorship W2773279968A5044174191 @default.
• W2773279968 hasAuthorship W2773279968A5044694911 @default.
• W2773279968 hasAuthorship W2773279968A5046382872 @default.
• W2773279968 hasAuthorship W2773279968A5055757758 @default.

• next