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- W2773346619 abstract "L’ovogenèse est un processus cellulaire et moléculaire complexe dont les mécanismes fondamentaux restent encore mal décrits ou non encore élucidés surtout dans l’espèce humaine. Le développement d’un modèle d’ovogenèse in vitro, en particulier pendant le développement fœtal humain, est une étape critique qui permettrait : (i) de mieux comprendre les mécanismes biologiques de l’ovogenèse (ii) d’affiner le diagnostic médical chez les femmes souffrant d’infertilité et (iii) de proposer de nouvelles thérapeutiques pour les pathologies de la reproduction. La genèse de ce modèle pourrait être envisagée à partir des cellules iPS. Dans cet article, nous retracerons les mécanismes physiologiques de l’ovogenèse in vivo et discuterons les travaux réalisés dans le domaine de l’ovogenèse in vitro à partir des cellules ES/iPS ainsi que les défis à relever dans le futur. Oogenesis is a complex cellular and molecular process whose fundamental mechanisms are still poorly described or not yet elucidated, especially in human species. The development of an in vitro model of oogenesis, particularly during fetal development in humans, is a critical step that would allow: (i) a better understand of the biological mechanisms of oogenesis; (ii) a refinement of medical diagnosis for women suffering from infertility; and (iii) providing new therapeutics for reproductive pathologies. The genesis of this model could be considered from ES/iPS cells. In this article, we will trace the physiological mechanisms of oogenesis in vivo and discuss the studies carried out in the field of in vitro oogenesis from ES/iPS cells, as well as the challenges to be met in the future." @default.
- W2773346619 created "2017-12-22" @default.
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- W2773346619 date "2018-01-01" @default.
- W2773346619 modified "2023-10-18" @default.
- W2773346619 title "Ovogenèse in vitro : quel chemin parcouru ?" @default.
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- W2773346619 doi "https://doi.org/10.1016/j.gofs.2017.11.004" @default.
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